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| Analysis on Efficacy of Cimetidine and Interferon combined with Zinc Supplement in treatment of Rotavirus Infectious Diarrhea in Children |
| WANG Daoli, WANG Qian, HE Aling |
| Northwest Women's and Children's Hospital, Shaanxi Xi'an 710061, China |
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Abstract Objective: To study the application effects of cimetidine and interferon combined with zinc supplement in the treatment of rotavirus infectious diarrhea in children. Methods:180 children patients with rotavirus infectious diarrhea admitted to our hospital from January 2017 to January 2018 were randomly divided into observation group (cimetidine + interferon+zinc supplement, n=90) and control group (cimetidine+interferon, n=90). The treatment effects were observed in the two groups. Results:The stool recovery time, dehydration correction time and body temperature recovery time in observation group were significantly shorter than those in control group (P<0.05). After 3 d of treatment, the negative conversion rate of fecal rotavirus antigen in observation group was significantly higher than that in control group (P<0.05), and the effective rate of treatment was significantly better than that in control group (P<0.05). After 10 d of treatment, the blood zinc levels in the two groups were significantly higher than those before treatment (P<0.05), and the increase in observation group was significantly greater than that in control group (P<0.05), and the blood zinc level in observation group after treatment was significantly higher than that in control group (P<0.05). At 3 months of telephone follow-up, the recurrence rate was 8.89% in observation group and was 20.00% in control group, and there was a significant difference in the recurrence rate between the two groups (χ2=4.23, P<0.05). Conclusions: Zinc supplementation with cimetidine and interferon has a good application value in children with RV infectious diarrhea. It can alleviate the clinical symptoms of children in a short time, promote the negative reaction of RV antigen, improve the treatment effect and reduce the recurrence rate in later period. It is worthy of clinical promotion.
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2019, Vol. 25 
