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| Clinical Efficacy of Wenyang Yixin Principle combined with Western Medicine in the treatment of Congestive Heart Failure |
| JING Yating, WANG Fengrong, LIU Yue |
| Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Liaoning Shenyang 110032, China |
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Abstract Objective: To explore the clinical efficacy of Wenyang Yixin principle combined with western medicine in the treatment of congestive heart failure (CHF). Methods: 202 patients with CHF were selected and randomly grouped according to the random number table method. Control group was treated with conventional western medicine, and observation group was treated with Wenyang Yixin principle based on control group. The efficacy of cardiac function was evaluated in the two groups. TCM symptoms scores and TCM syndrome efficacy were compared between the two groups before treatment and after 16 w of treatment, and levels of cardiac ultrasound indicators and serum copeptin and N-terminal pro-brain natriuretic peptide (NT-proBNP) were observed in the two groups before treatment and after 16 w of treatment. Results: The total effective rate of cardiac function in observation group was significantly higher than that in control group (97.03% vs 87.13%). After treatment, the scores of TCM symptoms of palpitations, asthma, chest pain, edema of extremities, cough and expectoration and oliguria were significantly reduced in the two groups (P<0.05), and the changes in observation group were significantly greater than those in control group (P<0.05). The total effective rate of TCM syndromes in observation group was significantly higher than that in control group (90.10% vs 71.29%). After treatment, the cardiac ultrasound indicator left ventricular end-systolic diameter (LVESD) in the two groups was significantly decreased (P<0.05) while the left ventricular ejection fraction (LVEF), cardiac output (CO) and mitral anterior blood flow E-to-A ratio (E/A) were significantly increased (P<0.05), and the changes of other indicators except the LVESD in observation group were significantly greater than those in control group (P<0.05). After treatment, the levels of serum copeptin and NT-proBNP were significantly decreased in the two groups (P<0.05), and the declines in observation group were significantly greater than those in control group (P<0.05). Conclusions: Wenyang Yixin principle combined with western medicine has significant efficacy on CHF, and it can effectively improve cardiac function, alleviate the related symptoms of heart failure, regulate the levels of copeptin and NT-proBNP, and benefit the prognosis of patients.
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2019, Vol. 25 
