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| Relationship between Serum IL-23 and IL-35 and Carotid Atherosclerotic Plaque Stability in Patients with Acute Cerebral Infarction |
| WANG Lin, QI Li, HE Wei, et al |
| 924 Hospital of PLA Joint Logistics Support Force, Guangxi Guilin 541000, China |
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Abstract Objective: To investigate the relationship between the serum levels of IL-23 and IL-35 and the stability of carotid atherosclerotic plaques in patients with acute cerebral infarction. Methods: 124 patients with acute cerebral infarction were divided into unstable plaque group, stable plaque group and non-plaque group according to the results of carotid ultrasonography, and 63 healthy people were selected as control group. Serum levels of IL-23 and IL-35 were compared in each group. Results: The level of serum IL-35 (18.8±6.7) ng/ml in the acute cerebral infarction group was significantly higher than that in the control group (8.7±4.1) ng/ml (P<0.01); the level of serum IL-23 (24.3±4.8) ng/ml in the acute cerebral infarction group was significantly higher than that in the control group (8.4+1.6) ng/ml (P<0.01). Academic significance (P<0.01). Serum IL-35 level (22.3±5.8) ng/ml in patients with unstable plaque was significantly higher than that in patients with stable plaque (15.3±1.6) ng/ml in patients with unstable plaque (P<0.01); serum IL-35 level (22.3±5.8) ng/ml and (15.3+1.6) ng/ml in patients with unstable plaque and patients with stable plaque were significantly higher than those in patients without plaque (10.7±4.1) ng/ml in patients with unstable plaque (P<0.01). The serum IL-23 level (36.9+6.4) ng/ml in unstable plaque group was significantly higher than that in stable plaque group (23.4±4.7) ng/ml (P<0.01); the serum IL-23 level (36.9±6.4) ng/ml and (23.4±4.7) ng/ml in unstable plaque group and stable plaque group were significantly higher than those in non-plaque group (11.4±1.6 ) ng/ml, the difference was statistically significant (P<0.01). Conclusion: The serum levels of IL-23 and IL-35 in patients with acute cerebral infarction may be related to the stability of carotid atherosclerotic plaque.
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2019, Vol. 25 
