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| Effects of Flurbiprofen Axetil Combined with Dezocine on Hemodynamics and Postoperative Analgesia Effects in Patients Undergoing Radical Resection of Colon Cancer |
| XIE Peng, LI Haiying , XU Jing, et al |
| Xi'an High-tech Hospital, Shaanxi Xi'an 710075, China |
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Abstract Objective:To analyze the effects of flurbiprofen axetil combined with dezocine on hemodynamics and postoperative analgesia effects in patients undergoing radical resection of colon cancer. Methods: A total of 94 patients undergoing radical resection of colon cancer admitted to our hospital from January 2016 to December 2018 were selected and divided into observation group and control group according to the random number table method, with 47 cases in each group. The two groups were given patient-controlled intravenous analgesia (PCIA), and control group was treated with dezocine formula (30 mg), and observation group was given formula of flurbiprofen axetil (150 mg) and dezocine (30 mg). Heart rate (HR) and mean arterial blood pressure (MAP) were routinely monitored before surgery, at the end, the 12 h , the 24 h and the 48 h after surgery. At 2 h, 4 h, 8 h, 12 h and 24 h after surgery, the pain level was evaluated by visual analogue scale (VAS), and the postoperative sedation effects were evaluated by sedation degree score (Ramsay). The occurrence of adverse reactions was recorded in the two groups. Results:The changes of HR and MAP values in observation group were significantly lower than those in control group before surgery and at different time points after surgery (P<0.05). At different time points after surgery, the VAS score and Ramsay score in observation group were significantly lower than those in control group (P<0.05). The incidence rate of adverse reactions in observation group was significantly lower than that in control group (6.38% vs 21.28%) (χ2=4.374, P=0.036). Conclusions:Flurbiprofen axetil combined with dezocine can effectively maintain hemodynamic stability and relieve postoperative pain of patients after radical resection of colon cancer.
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[1] Tesniere A, Schlemmer F, Boige V, et al. Immunogenic death of colon cancer cells treated with oxaliplatin[J]. Oncogene, 2016, 29(4):482~491.
[2] Afrin S, Giampieri F, Gasparrini M, et al. Chemopreventive and therapeutic effects of edible berries: a focus on colon cancer prevention and treatment[J]. Molecules, 2016, 21(2):169~208.
[3] Agrawal R,Lee C S,Gonzalez-Lopez J J,et al.Flurbiprofen:a nonselective cyclooxygenase(COX) inhibitor for treatment of noninfectious,non-necrotizing anterior scleritis[J].Ocular Immunology&Inflammation,2016,24(1):35~42.
[4] 张麟临,赵亓,王新,等.氟比洛芬酯复合地佐辛预防瑞芬太尼复合麻醉患者术后痛觉过敏的效果[J].中华麻醉学杂志,2016,36(4):392~395.
[5] 范海哲,张婧杰.不同剂量地佐辛复合氟比洛芬酯在下肢骨折手术术后镇痛的效果[J].临床麻醉学杂志,2014,30(10):1001~1004.
[6] 麦伟良.地佐辛与氟比洛芬酯对乳腺癌围术期镇痛效果与免疫抑制的影响[J].重庆医学,2015,44(14):1970~1972.
[7] 林翠玲,宋世辉,史亚洲,等.术毕前静注地佐辛和氟比洛芬酯的胸腔镜手术患者复苏期血流动力学、气管插管拔除时间观察[J].山东医药,2018,58(11):88~90. |
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2019, Vol. 25 
