急性呼吸窘迫综合征患者血清HSP70和硫化氢水平变化与预后的关系

doi:10.3969/j.issn.1006-6233.2019.08.008

Abstract
Figure/Table
References
Related Citation (4)

Download: PDF (1379 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective: To detect the levels of serum heat shock protein 70 (HSP70) and hydrogen sulfide (H₂S) in patients with acute respiratory distress syndrome (ARDS), and to analyze their relationships with the prognosis of the disease. Methods: 90 patients with ARDS admitted to our hospital from May 2015 to May 2018 were divided into 49 cases in death group and 41 cases in survival group. Enzyme linked immunosorbent assay (ELISA) was used to detect serum HSP70 and H₂S levels, all subjects were scored by APACHE- II, the inhaled oxygen concentration (FiO2) and arterial partial pressure of oxygen (PaO2) were measured by blood gas analyzer, and the oxygenation index was calculated. Results: The APACHE-II score in the death group was significantly higher than that in the survival group (P<0.05), the oxygenation index in the death group was significantly lower than that in the survival group (P<0.05), the number of extrapulmonary ARDS in the death group was significantly higher than that in the survival group (P<0.05); serum H₂S and HSP70 levels of ARDS patients in the survival group were significantly higher than those in the death group (P<0.05); the serum levels of H₂S and HSP70 in severe ARDS patients were significantly lower than those in moderate ARDS patients (P<0.05), and the serum levels of H₂S and HSP70 in moderate ARDS patients were significantly lower than those in mild ARDS patients (P<0.05); ROC curve analysis showed that serum H₂S and HSP70 levels alone detections had certain values in predicting the prognosis of ARDS patients; the combined detection of AUC was 0.885, sensitivity was 77.60%, specificity was 92.90%; multivariate analysis showed that APACHE-II score, oxygenation index, serum H₂S level, and serum HSP70 level were independent risk factors affecting the prognosis of patients. Conclusion: The serum H₂S and HSP70 levels in ARDS survival group are increased significantly, lower oxygenation index (PaO₂/FiO₂), lower serum H₂S level, and lower serum HSP70 level are risk factors for all-cause mortality in ARDS patients within 30 days, which may be a biomarker of prognosis of ARDS.

Key words： Acute respiratory distress syndrome Heat shock protein 70 Hydrogen sulfide

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	SHI Yubin
	GAO Xinhai
	SHEN Yangfan
	et al

Cite this article:

SHI Yubin,GAO Xinhai,SHEN Yangfan, et al. Changes of Serum HSP70 and Hydrogen Sulfide Levels in Patients with Acute Respiratory Distress Syndrome and Their Relationships with Prognosis[J]. HeBei Med, 2019, 25(8): 1261-1264.

URL:

http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2019.08.008 OR http://www.hbyxzzs.cn/EN/Y2019/V25/I8/1261

[1] 刘妍,朱光发.心脏术后急性呼吸窘迫综合征危险因素的研究进展[J].临床肺科杂志,2017,22(10):1893~1896.
[2] 郭彦利,邱颖,陈满秋.急性呼吸窘迫综合征的生物标志物研究进展[J].中华急诊医学杂志,2016,25(4):542~545.
[3] 金伟,夏勇军,李雪榕,等.大鼠脑震荡伤后脑外主要器官热休克蛋白70、C-fos表达比值与损伤时间关系的研究[J].华西医学,2017,32(10):1539~1543.
[4] 王乐,巴依尔才次克,李明霞.热休克蛋白70对缺氧性肺动脉高压新生大鼠肺的保护作用[J].中华实用儿科临床杂志,2017,32(6):451~456.
[5] 薛文龙,蔡文杰,陶蓓蓓,等.介导硫化氢生理/病理学效应的靶分子及其分子开关调节的原子生物学机制[J].生理科学进展,2017,48(1):12~21.
[6] 黎檀实,何权瀛.对AECC制定的ARDS诊断标准的再讨论[J].中华危重病急救医学,2009,21(4):196~198.
[7] 陆任林.急性呼吸窘迫综合征患者肺内和肺外源性因素分析研究[J].当代医学,2014(24):75~76.
[8] 刘佳,朱余兵.血必净对脓毒症急性肺损伤大鼠氧化应激及炎性因子表达的影响[J].现代中药研究与实践,2016,30(1):33~35.
[9] 唐雪峰,李建柱,赵存真,等.热休克蛋白70生物学功能及在家禽组织中的表达[J].畜牧与兽医,2018,50(4):144~148.
[10] 王乐,赵婷,李明霞.腺病毒介导的热休克蛋白70对新生大鼠肺组织热休克蛋白70表达水平的影响[J].新疆医科大学学报,2017,40(7):923~927.
[11] 何淼,计高荣,熊旭东,等.炎调方对巨噬细胞中HSP70表达及其效应的影响[J].上海中医药大学学报,2017,31(6):76~79.
[12] 周丽芬,林启旺,廖莉,等.外源性H₂S干预对O3致哮喘小鼠气道反应性和气道重塑的影响[J].中国病理生理杂志,2016,32(2):347~351.
[13] Zhao M P, Chu-Lei M, Zhang C C, et al. The effects and mechanisms of ligustrazine injection on pulmonary arterial hypertension in COPD patients[J]. Chinese Journal of Applied Physiology, 2016, 32(5):408~412.