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| Correlation Analysis between LH E2 and P in Follicular Fluid and Female Age |
| XU Maoqing, et al |
| Medical College of Nanchang University, Jiangxi Nanchang 330006, China |
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Abstract Objective: To analyze the correlation between LH, E2 and P in follicular fluid and female age by measuring the levels of luteotropic hormone (LH), estradiol (E2) and progesterone (P) in follicular fluid of infertile women in different age groups. Methods: A total of 140 patients who received IVF-ET/ICSI assisted pregnancy from July 2017 to June 2018 were enrolled in the study. They were divided into groups A, B, and C according to age, and group A (<35 years old, n=55), group B (35-39 years old, n=55), group C (>39 years old, n=30), ELISA was used to detect the levels of LH, E2 and P in follicular fluid on day of egg retrieval, and three groups of infertility were analyzed. General information of patients with disease, the difference of LH, E2, P levels of follicular fluid on the day of egg retrieval and comparison of the number of eggs obtained in different age groups, fertilization rate, available embryo rate, high quality embryo rate, clinical pregnancy rate. Results: There were no significant differences in BMI between the general data of group A, group B and group C (P>0.05), but there were significant differences in age, basal serum follicle stimulating hormone (bFSH) and antral follicle (AFC). P<0.05); the difference of LH level and E2 level in follicular fluid of group A, group B and group C was statistically significant (P<0.05), but the level of follicular fluid P in the three groups was taken. The difference was not statistically significant (P>0.05). According to Spearman correlation analysis, the LH level of follicular fluid was positively correlated with female age (r=0.335, P<0.05), and E2 level was negatively correlated with female age (r= -0.418, P<0.05), there was no correlation between P level and female age (r=0.045, P=0.523). There were significant differences in the number of eggs, fertilization rate and multi-PN fertilization rate in group A, B and C. Significance (P<0.05), but there was no significant difference in available embryo rate, high quality embryo rate and clinical pregnancy rate (P>0.05). Conclusion: The levels of LH and E2 in follicular fluid are related to age. The ovarian reserve function is related to age, bFsh and AFC. The age of 35~39 years old is the beginning of the decline of ovarian reserve function, and the ovarian response (reflected by the number of eggs) is also followed. Decreased, especially in women over the age of 39, ovarian reserve dysfunction is evident, and ovarian response is also dramatically reduced.
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2019, Vol. 25 
