乌司他丁对老年髋关节置换术后认知功能及血浆IL-6 IL-10 BDNF和S100β的影响

doi:10.3969/j.issn.1006-6233.2019.07.016

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Abstract Objective: To investigate the correlation between MMSE score and plasma IL-6,IL-10,BDNF and S100β after hip arthroplasty in elderly patients and the improvement of ulinastatin. Methods: 92 elderly patients undergoing hip arthroplasty in our hospital from April 2016 to April 2018 were selected and randomly divided into control group and experimental group according to random number table method.All patients were given intravenous access and multi-function monitor for vital signs monitoring. The experimental group was given 5 000 U/kg Ulinastatin intravenously before and after anesthesia, while the control group was given the same volume of physiological saline. Simple mental state scale was used to evaluate the cognitive function of the two groups before and after operation. The changes of plasma levels of IL-6, IL-10, BDNF and S100 beta were compared between the two groups before and after operation. Results: There were 7 cases(15.22%)in the control group and 1 cases (2.17%) in the trial group with postoperative cognitive impairment. The difference between the two groups was statistically significant ( P<0.05). There was no significant difference in MMSE score between the two groups before operation (t = 0. 329, P>0. 05). The MMSE score of the control group was (25.34±1.28) on the 3rd day after operation, which was significantly lower than that before the treatment (29.32±2.34), and the difference was statistically significant (t=4.283, P<0.05). The MMSE score of the patients in the trial group was (28.52±1.27) on the 3rd day after operation, which was significantly higher than that in the control group (25.34±1.28), and the difference was statistically significant (t = 4.132, P<0. 05). The levels of IL-6 and IL-10 at the end of operation and on the third day after operation in both groups were significantly higher than those before treatment (P<0. 05). The IL-6 of the patients in the trial group was significantly lower than that in the control group at the end of operation and the third day after operation (all P<0. 05). On the 3rd day after operation, the level of BDNF was significantly lower than that before operation (all P<0. 05). The levels of S100β at the end of operation in both groups were significantly higher than those before treatment, and the levels of S100β at the end of operation in the trial group were significantly lower than those in the control group (all P<0.05). Conclusion: The use of ulinastatin in perioperative hip replacement patients can effectively improve their cognitive function and plasma IL-6,IL-10,BDNF and S100β levels, which is worthy of extensive clinical application.

Key words： Hip replacement Ulinastatin Cognitive function Gerontal patient

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	JING Xu

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JING Xu. Effect of Statine on Cognitive Function and Plasma IL-6 IL-10 BDNF and S100 Beta in Elderly Patients after Hip Arthroplasty[J]. HeBei Med, 2019, 25(7): 1116-1119.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2019.07.016 OR http://www.hbyxzzs.cn/EN/Y2019/V25/I7/1116

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