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| Study on the Correlation between Depression Occurrence Mechanism and Serum Thyroid Hormone and Adrenocortical Hormone Levels in Elderly Patients |
| XU MoJu |
| The People's Hospital in Langfang, Hebei Langfang 065000, China |
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Abstract Objective: To explore the correlation between depression occurrence mechanism and serum thyroid hormone and adrenocortical hormone levels in elderly patients. Methods: 80 elderly patients suffering from depression of the study group were divided into the mild depression group(42) , moderate depression(26) and the severe depression group(12), according to the quantitative score points for by Zung depression score (ZDS)and Zung Anxiety score (ZAS). 80 people were selected for health examination during the same period, as control group. Thyroid hormone and adrenocortical hormone levels and serum potassium were detected by chemiluminescence, then, The correlation between depression and glucocorticoid and thyroxine levels was analyzed. Results: Compared with the control group, the quantitative scores of depression and anxiety in elderly patients increased significantly (P < 0.05), TSH increased, T3, FT3, FT4 decreased, and there were significant differences (P < 0.05). Compared with the control group, the levels of serum free COR, ACTH, blood potassium and 24-hour UFC in depressive patients at 8:00 and 16:00 were significantly lower than those in the control group (P < 0.01), and the levels of serum free COR were significantly lower than those at 16:00 (P < 0.01). Compared with mild and moderate depression group, the levels of thyroid hormone and adrenocortical hormone in severe depression group decreased significantly (P < 0.01). Conclusion: With the increase of the severity of depression, the levels of thyroid hormone and adrenocortical hormone will gradually decrease, which may be one of the mechanisms of depression in elderly patients.
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[1] 40 Alexopoulos GS, Achultz SK, Lebowitz BD. Late-life depression : a model for medical classification[J]. Biol Psychiatry,2005,58(4):283~289.
[2] Talwar A, Sahni S, Kim EJ, et al. Dyspnea, depression and health related quality of life in pulmonary arterial hypertension patients[J].Exerc Rehabil, 2015,11(5):259~265.
[3] Hatzinger M, Brand S, Perren S, et al.Hypothalamic-pituitary-adrenocortical (HPA) activity in kindergarten children: importance of gender and associations with behavioral/emotional difficulties[J].Psychiatr Res, 2007,41(10):861~870.
[4] Schneider G, Nienhaus K, Gromoll J, et al.Sex hormone levels, genetic androgen receptor polymorphism, and anxiety in ≥50-year-old males[J].Sex Med, 2011,8(12):3452~3464.
[5] Talaei A, Rafee N, Rafei F, et al. TSH cut off point based on depression in hypothyroid patients[J].Chehrei A.BMC Psychiatry,2017,17(1):327. |
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2019, Vol. 25 
