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| The Relationship Between the Level of MiR-19a in Peripheral Blood with BNP and Heart Function of Patients with Ischemic Heart Failure |
| LI Yongzheng, LIU Yang, WANG Jing , et al |
| Yicheng People's Hospital of Hubei, Hubei Yicheng 441400, China |
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Abstract Objective: To investigate the relationships between the level of miR-19a in peripheral blood with brain natriuretic peptide (BNP) and heart function of patients with ischemic heart failure. Methods: According to the NYHA classification of heart function, 100 patients with ischemic heart failure were divided into 35 cases of grade II, 42 cases of grade III, 23 cases of grade IV, another 50 healthy persons in the same period were selected as control group. Left ventricular ejection fraction (LVEF), left ventricular anteroposterior diameter (LAD) and left ventricular end-diastolic diameter (LVEDD) were measured by echocardiogram, the serum BNP level was measured by electrochemiluminescence immunoassay, real time fluorescence quantitative PCR (qRT-PCR) was used to detect the expression of miR-19a in peripheral blood, Pearson correlation analyzed the correlations between miR-19a, BNP with LVEF, LAD, LVEDD, receiver operating characteristic curve (ROC) was used to assess the predictive values of miR-19a and BNP for cardiac function classification in patients with ischemic heart failure. Results: Alanine aminotransferase, aspartate aminotransferase, creatinine, urea nitrogen, uric acid and blood glucose in the ischemic heart failure group were significantly higher than those in the control group, while hemoglobin and total cholesterol were significantly lower than those in the control group (P<0.05). With the increase of NYHA grade, LAD and LVEDD gradually increased, LVEF gradually decreased, BNP and miR-19a expressions gradually increased (P<0.05). BNP was positively correlated with LAD and LVEDD (r = 0.382, r = 0.358, P<0.000) and negatively correlated with LVEF (r = - 0.402, P<0.000). MiR-19a was positively correlated with LAD and LVEDD (r = 0.415, r = 0.336, P<0.000), and negatively correlated with LVEF (r = - 0.392, P<0.000). The AUC value of BNP for predicting grade III of heart function was 0.753, and the AUC value of BNP for predicting grade IV of heart function was 0.704. The AUC value of miR-19a for predicting grade III of heart function was 0.838, and the AUC value of miR-19a for predicting grade IV of heart function was 0.795. Conclusion: MiR-19a and BNP levels in peripheral blood of patients with ischemic heart failure are increased, which are positively correlated with cardiac function parameters and con be used as predictors of cardiac function classification.
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2019, Vol. 25 
