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| Logistic Regression Analysis of Influencing Factors of Fetal Birth Failure after IVF-ET Successful Pregnancy |
| CHEN Yun, YANG Xiaojie, HE Hua, et al |
| Tangshan Maternal and Child Health Hospital, Hebei Tangshan 063000, China |
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Abstract Objective: To explore the related factors influencing the failure of fetal birth after successful pregnancy of vitro fertilization-embryo transfer (IVF-ET) and to put forward preventive suggestions. Methods: The clinical datas of 247 cases of pregnant women after successful pregnancy of IVF-ET in our hospital were retrospectively analyzed from August 2015 to January 2018, and the patients were divided into successful group and failure group according to hether or not success baby birth, then the risk factors of infant success after successful pregnancy of IVF-ET were analyzed by single factor analysis and multiple factor Logistic regression analysis method, and put forward the prevention suggestions. Results: After follow-up, there were 206 cases with success baby birth in the 247 cases after successful pregnancy of IVF-ET and there were 41 cases with failed baby birth, and the failure rate of live births was 16.60%. There was no significant difference of the constituent ratios of the infertility years ≥ 6 years, primary infertility, with birth history, with ectopic pregnancy history, the number of embryos transferred ≥ 2, embryo transfer during freeze-thaw cycles, artificial cycle of embryo transfer and the short protocol, long protocol, super long protocol and antagonist protocol of the control ovary hyperstimulating protocol between the successful group and the failure group (P>0.05). The constituent ratios of the age ≥ 35 years old, history of abortion, history of assisted reproduction, history of uterine surgery, endometrial thickness on HCG injection day ≤10mm, depression, LH/FSH > 2 and fetal reduction of the successful group were significantly lower than those of the failure group, and the differences were statistically significant (P<0.05), and Logistic regression analysis showed that these factors were the risk factors for successful baby birth of the patients after successful pregnancy of IVF-ET (OR = 3.518, 2.962, 5.147, 5.007, 5.425, 4.932, 4.763, 4.294, all Ps<0.05). Conclusion: Older pregnant women, abortion history, assisted reproductive history, uterine surgery history, endometrial thickness on HCG injection day ≤10mm, depression, LH/FSH > 2 and fetal reduction all are risk factors of affecting the success baby birth after successful pregnancy of IVF-ET, which can increase the risk of infant failure, and the clinical work needs to strengthen the management of such patients.
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2019, Vol. 25 
