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| Curative Effect of Gamma Globulin combined with Prednisone in treatment Myasthenia Gravis and its Effect on Serum AchRAb TGF-β1 and Complement |
| JIAO Nianhui |
| Laiwu People's Hospital in Shandong, Shandong Lanwu 271100, China |
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Abstract Objective: To discuss the curative effect ofgamma globulin combined with prednisone in treatment myasthenia gravis and its effect on serum Acetylcholine receptor antibody (AchRAb), transforming growth factor-β1 (TGF-β1) and complement. Methods: 99 patients with myasthenia gravis who treated from January 2014 to April 2018 in our hospital, according to the simple random number table method these patients were divided into 56 control group and 43 observation group. The control group was treated with prednisone, and the observation group was treated with gamma globulin on the basis of the control group. Then clinical efficacy,absolute score of muscular weakness, levels of AchRAb, TGF-β1, complement at different time points,and adverse reactions occurred in both groups were compared. Results: After treatment, the total effective rate of the observation group was higher than that of the control group, the difference was statistically significant (P<0.05). Before treatment, absolute score, levela of AchRAb, TGF-β1 and complement in both group were no statistically significant difference (P>0.05). 3 months after treatment and at the end of treatment, the absolute score of muscular weakness and level of AchRAb in both groups were decreased, and the levels of TGF-β1 and complement in the observation group were lower than those in the control group, while those in the observation group were higher than those in the control group, there were statistically significant differences in absolute scores, AchRAb, TGF- 1 and complement levels between the two groups in terms of treatment methods and treatment time (P<0.05). Fatigue, appetite loss, blood pressure drop and weight gain occurred in both groups, and there was no statistical difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: The curative effect of gamma globulin combined with prednisone in the treatment of myasthenia gravis is superior to that of prednisone, which can reduce the serum AchRAb level, promote the expression of TGF-β1 and complement, and is safe and reliable.
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2019, Vol. 25 
