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| Effects of Ulinastatin on Inflammatory Factors Coagulation Function and Cognitive Function in Elderly Patients Undergoing Hip Replacement Surgery |
| WEI Zhixian, PEI Zifeng |
| The Second Affiliated Hospital of Shenyang Medical College, Liaoning Shenyang 110002, China |
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Abstract Objective: To analyze the effects of ulinastatin on inflammatory factors, coagulation function and cognitive function in elderly patients undergoing hip replacement. Methods: A total of 128 elderly patients undergoing hip arthroplasty who were treated in our hospital from August 2016 to December 2017 were enrolled. All patients were divided into control group (n=64 cases) by random number table method. Study group (n=64 cases). Patients in the control group were given normal saline during the perioperative period, and patients in the study group were given ulinastatin during the perioperative period. Venous blood was collected from all patients before and immediately after surgery, 1, 2, and 3 days to detect interleukin-6 (IL-6), detect interleukin-8 (IL-6), and CRP levels; Prothrombin time (PT), partial thrombin time (APTT), thrombin time (TT) were measured at 3 days after surgery and cognitive function was assessed by the patient's simple intelligence state test (MMSE).Results: The levels of IL-6, IL-6 and CRP in the two groups reached a peak after the operation, and then gradually decreased. However, the postoperative study group was lower than the control group, and IL-8 and CRP were in operation. Immediately after and 1 and 2 days after surgery, the difference was statistically significant (P<0.05). At 3 days after operation, the PT, APTT and TT of the study group were significantly better than the control group, and the difference was statistically significant (P<0.05). The MMSE score of the control group was significantly lower than that of the preoperative group, and the difference was statistically significant (P<0.05).Conclusion: Ulinastatin can improve the hypercoagulable state of patients with senile hip replacement by inhibiting inflammatory reaction, and effectively prevent postoperative cognitive dysfunction. It is worthy of clinical promotion.
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2019, Vol. 25 
