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| The Relation between Plasma Glucose and Serum CA199 Levels in Physical Examination People |
| NIE Qian, WANG Zhongli, HAO Zhihua, et al |
| Hebei Provincial People's Hospital, Hebei Shijiazhuang 050051, China |
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Abstract Objective: To investigate the relationship between plasma glucose and serum CA199 levels in physical examination people. Methods: A total of 2868 people aged 40-80 years were enrolled retrospectively from one medical center for physical examination of Hebei. According to CA199 level, all people were divided into negative group (<34U/ml) and positive group (≥34U/ml). Clinical data were compared between the two groups. The kinds of clinical data and the change of CA199 were compared according to different level of plasma glucose. Results: Compare with CA199 negative group, the levels of HbA1c, FPG, AST and ALT (P＜0.05) were significantly higher in CA199 positive group. The sex, age, BMI, SBP, DBP, TG, TC, LDL-C, HDL-C, BUN, Scr, SUA, γ-GGT, Hcy, WBC, NEUT, LYM between the two groups were no significant differences (P＞0.05). With the increase of HbA1c, the levels of CA199 were significantly higher (P＜0.01). Pearson analysis showed that the level of CA199 was positively correlated with FPG(r=0.272,P＜0.01), HbA1c(r=0.289, P＜0.01), AST(r=0.112, P＜0.01), ALT(r=0.087, P＜0.05). Multiple logistic regression analysis showed that FPG and HbA1c were associated with CA199 (OR=1.903,2.243,P=0.012,0.005) . Conclusion: The level of serum CA199 was affected by FPG and HbA1c in healthy people. Poor control of blood sugar was related to the increase of CA199.
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2019, Vol. 25 
