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| Changes of Related Factors of Gastrointestinal Motility Disorders in Rabbit Models of Severe Acute Pancreatitis |
| WANG Gang, HAN Junling, WANG Fang, et al |
| The First Hospital of Qinhuangdao, Hebei Qinhuangdao 066000, China |
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Abstract Objective: To study the related factors of gastrointestinal motility disorder in rabbits with severe acute pancreatitis. Methods: 30 New Zealand SPFrabbits were randomly divided into control group and experimental group, 15 rabbits in each group. The rabbits in the experimental group were established by injection of sodium taurocholatethrough pancreatic duct, and the rabbits in the control group were operated through the experimental group, but injected with equal volume distilled water.After 24h, the general condition of the rabbit's abdominal cavity was observed, the gastrointestinal transmission index (TI) was calculated, and the serum levels of GAS, MTL, SP, VIP, CCK, TNF- a, IL-1 and IL-6 were detected. The pathological sections of the pancreas were made, under the microscope, and the pathological score was observed. Results:In the experimental group, a large number of turbidity ascites, many saponification spots, large hemorrhage and necrosis of the pancreas, obvious hyperemia and edema of the gastrointestinal tract accompanied by partial necrosis were found in the abdominal cavity. The widening of the interleaf space of the pancreas tissue, the edema of the cells, the necrosis of some acinar cells and a large number of inflammatory cells infiltrated in the experimental group.The TI in the experimental group was lower than the control group, and PSP was significantly higher(P<0.05); The concentrations of GAS, SP and VIP in the experimental group were higher, and the concentration of MTL、CCK was lower(P<0.05). The concentrations of TNF-α, IL-1 and IL-6 in the experimental group were higher(P<0.05).Conclusion: SAP white rabbits have gastrointestinal motility disorders, which are closely related to the abnormal expression of gastrointestinal hormones and inflammatory factors.
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2019, Vol. 25 
