孟鲁司特钠用于急性发作期支气管哮喘患儿的临床效果及对CD4+ CD8+及CD4+/CD8+水平的影响

doi:10.3969/j.issn.1006-6233.2019.01.008

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Abstract Objective: To explore the clinical effect of montelukast sodium in children with acute attack of bronchial asthma and its influence on CD₄⁺, CD₈⁺ and CD₄⁺/CD₈⁺ levels. Methods: 76 children with acute attack of bronchial asthma in our hospital from June 2015 to June 2018 were selected and randomly divided into observation group and control group, 38 cases in each group. The control group was treated with routine oxygen inhalation and fluid replacement, while the observation group was treated with montelukast sodium. The levels of CD₄⁺, CD₈⁺, CD₄⁺/CD₈⁺, forced vital capacity (FVC), peak expiratory flow (PEF), forced expiratory volume (FEV1), changes of symptom score and improvement time of symptoms were compared between the two groups before and after treatment. Results:After treatment, the levels of CD₄⁺, CD₄⁺ /CD₈⁺ in the immune function of the observation group were significantly higher than those of the control group [(39.25±7.15)% vs (32.87±6.38)%, (1.89±0.53) vs (1.37±0.54)] (P<0.05), and the level of CD₈⁺ was significantly lower than that of the control group [(25.06±8.04)% vs (30.54±6.26)%] (P<0.05); The FVC, PEF and FEV1 in the observation group were higher than those in the control group [(79.24±7.11)% vs (68.48±5.26)%,(1.40±0.44)L/s vs (1.17±0.34)L/s, (76.55±3.55)% vs (65.85±3.46)%] (P<0.05); The symptom relief, time and signs disappeared in the observation group, all lower than those in the control group [(3.34±0.75)d vs (5.64±1.05)d, (5.22±1.17)d vs (7.62±1.55)d] (P<0.05); The daily symptom score and night symptom score of the observation group were lower than that of the control group [(1.12±0.45) score vs (1.63±0.58) score, (1.16±0.46) score vs (2.03±0.75) score] (P<0.05). Conclusion:On the basis of routine treatment for children with acute attack of bronchial asthma, montelukast sodium treatment can effectively improve the immune function and lung function of children, shorten the treatment time, and have a significant effect.

Key words： Montelukast sodium Bronchial asthma Immune index

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	Articles by authors
	CHEN Liang
	LIN Yuantao
	ZHOU Hongyu

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CHEN Liang,LIN Yuantao,ZHOU Hongyu. Montelukast Sodium in the Treatment of Children with Acute Attack of Bronchial Asthma and the effect on the CD₄⁺ CD₈⁺ and CD₄⁺/CD₈⁺ Levels[J]. HeBei Med, 2019, 25(1): 30-33.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2019.01.008 OR http://www.hbyxzzs.cn/EN/Y2019/V25/I1/30