紫杉醇卡铂联合康莱特对宫颈癌患者血管生成及侵袭能力的影响

doi:10.3969/j.issn.1006-6233.2018.12.021

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Abstract Objective: To study the effect of paclitaxel, Carboplatin combined with Kanglaite on angiogenesis and invasion of cervical cancer patients. Methods: Eighty-seven cervical cancer patients admitted to our hospital from August 2013 to July 2014 were selected and divided into control group (46 cases) and observation group (41 cases) according to the order of inpatient medical records has been successively. The control group was treated with paclitaxel and carboplatin, and the observation group was combined with Kanglaite injection to complete the treatment, 3 weeks for a course of treatment, continuous treatment of 4 courses. The clinical efficacy, tumor microvessel density (MVD), vascular endothelial growth factor (VEGF), immune function, quality of life, and survival were compared between the two groups. Results: After treatment, the total clinical efficacy of the observation group was significantly higher than that of the control group (P<0.05). Before treatment, there was no significant difference in tumor microvessel density (MVD) and vascular endothelial growth factor (VEGF) levels between the two groups (P>0.05). After treatment, the MVD and VEGF levels in the observation group were significantly lower than those in the control group (P<0.05). Before treatment, there was no significant difference in the levels of CD3⁺, CD4⁺, and CD8⁺ between the two groups (P>0.05). After treatment, the levels of CD3⁺, CD4⁺, and CD8⁺ in the observation group were significantly higher than those in the control group (P<0.05). Before treatment, there was no significant difference in somatic function, subjective function, emotional function, social function, and cognitive function scores between the two groups (P>0.05). After treatment, physical function, self-consciousness function, emotional function, social function, and identification in the observation group was significantly higher than that of the control group (P<0.05). The 1-year, 2-year and 3-year survival rates in the observation group were significantly higher than those in the control group (P<0.05). Conclusion: Paclitaxel, carboplatin combined with Kanglaite can regulate angiogenesis in patients with cervical cancer, reduce the invasive ability of cervical cancer cells. It has a good clinical efficacy and good prognosis.

Key words： Paclitaxel Carboplatin Kanglaite Cervical cancer Angiogenesis

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	SHEN Xingyong
	XU Xin
	YUAN Ping
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Cite this article:

SHEN Xingyong,XU Xin,YUAN Ping, et al. Effect of Paclitaxel and Carboplatin combined with Kang Lai Te on Angiogenesis and Invasion in Patients with Cervical Cancer[J]. HeBei Med, 2018, 24(12): 2020-2025.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2018.12.021 OR http://www.hbyxzzs.cn/EN/Y2018/V24/I12/2020

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