阿奇霉素并脂溶性维生素对肺炎支原体肺炎患儿炎性免疫因子的影响

doi:10.3969/j.issn.1006-6233.2018.11.039

Abstract
Figure/Table
References
Related Citation (15)

Download: PDF (1232 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective: To study the effect of azithromycin combined with fatsoluble vitamin (FV) on inflammatory and immune factors of child patients with mycoplasma pneumoniae pneumonia(MPP). Methods: A total of 108 cases of MPP child patients treated in our hospital from December 2014 to November 2017 were included into this study, and divided into combination group and control group using the random number table method, with 54 cases in each group. Patients in control group were performed conventional therapy plus azithromycin sequential therapy, and based on this, patients in combination group were performed FV trerapy. The symptoms, improvement time of signs, hospitalization time, levels of serum inflammatory factors, immune factors and chemotactic factors before and after treatment of the two groups were observed. Results: The extinction time of dyspnea, cough and lung rale, fever clearance time and hospitalization time in combination group were shorter than those in control group (P<0.05). After treatment, the serum levels of IL-8, IL-10, IL-13 and TNF-α in combination group were lower than those in control group (P<0.05). The serum levels of C3, C4, IgA, IgM and IgG in combination group were lower than those in control group(P<0.05). The serum levels of CysLTs, MDC and MCP-4 in combination group were lower than those in control group (P<0.05). The total effective rate in combination group (96.30%) was higher than 77.78% in control group (P<0.05). Conclusion: Azithromycin combined with FV can effectively remove serum inflammatory factors, improve serum immune factors and chemokines in children with MPP. It is effective, safe and reliable.

Key words： Mycoplasma pneumoniae pneumonia Azithromycin Fatsoluble vitamin Inflammatory factors Immune factors

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	WANG Rongliang

Cite this article:

WANG Rongliang. Effects of Azithromycin combined with Fat Soluble Vitamins on Inflammatory and Immune Factors in Children with Mycoplasma Pneumoniae Pneumonia[J]. HeBei Med, 2018, 24(11): 1917-1921.

URL:

http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2018.11.039 OR http://www.hbyxzzs.cn/EN/Y2018/V24/I11/1917

[1] Kawamata R, Yokoyama K, Sato M, et al. Utility of serum ferritin and lactate dehydrogenase as surrogate markers for steroid therapy for Mycoplasma pneumoniae pneumonia[J].Infect Chemother, 2015, 21(11): 783~789.
[2] Lu A, Wang C, Zhang X, et al. Lactate dehydrogenase as a biomarker for prediction of refractory mycoplasma pneumoniae pneumonia in children[J]. Respir Care, 2015, 60(10): 1469~1475.
[3] 朱冰, 陈维宪,李敏妍.阿奇霉素联合孟鲁司特钠治疗小儿肺炎支原体肺炎的疗效及其对血清C反应蛋白水平的影响[J].临床和实验医学杂志,2015,14(1):41~43.
[4] Duggan SN, Smyth ND, O'Sullivan M, et al. The prevalence of malnutrition and fat-soluble vitamin deficiencies in chronic pancreatitis[J]. Nutr Clin Pract, 2014, 29(3): 348~354.
[5] 胡亚美, 江载芳.诸福棠实用儿科学[M].第7版.北京:人民卫生出版社,2003.1199.
[6] Miyashita N, Kawai Y, Inamura N, et al. Setting a standard for the initiation of steroid therapy in refractory or severe mycoplasma pneumoniae pneumonia in adolescents and adults[J].Infect Chemother, 2015, 21(3): 153~160.
[7] Jiang W, Yan Y, Ji W, Wang Y, et al. Clinical significance of different bacterial load of mycoplasma pneumoniae in patients with mycoplasma pneumoniae pneumonia[J]. Braz Infect Dis, 2014, 18(2): 124~128.
[8] Rodríguez F, Batista M, Hernandez JN, et al. Relationship between expression of interleukin-5 and interleukin-13 by epithelial cells and bronchiolar changes in pigs Infected with mycoplasma hyopneumoniae[J].Comp Pathol, 2016, 154(2~3): 165~168.
[9] Baumann R, Rabaszowski M, Stenin I, et al. Comparison of the nasal release of IL-4, IL-10, IL-17, CCL13/MCP-4, and CCL26/eotaxin-3 in allergic rhinitis during season and after allergen challenge[J]. Am Rhinol Allergy, 2013, 27(4): 266~272.
[10 Goldstein LH, Gabin A, Fawaz A, et al. Azithromycin is not associated with QT prolongation in hospitalized patients with community-acquired pneumonia[J]. Pharmacoepidemiol Drug Saf, 2015, 24(10): 1042~1048.
[11] Kim HJ, Jang JG, Hong KS, et al. Relationship between serum vitamin D concentrations and clinical outcome of community-acquired pneumonia[J]. Int Tuberc Lung Dis, 2015, 19(6):729~734.
[12] Jovanovich AJ, Ginde AA, Holmen J, et al. Vitamin D level and risk of community-acquired pneumonia and sepsis[J]. Nutrients, 2014, 6(6): 2196~2005.
[13] Hemila H. Vitamin E and the risk of pneumonia: using the I 2 statistic to quantify heterogeneity within a controlled trial[J]. Br Nutr, 2016, 116(9): 1530~1536.