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| The Effect of Video-assisted Thoracoscopy and Thoracotomy on the Treatment of Non-small Cell Lung Cancer and the Changes of Serum TGF-α CA21-1 |
| HUANG Hongling, DENG Zhongbiao, HUANG Jinqi, et al |
| Enshi Central Hospital, Hubei Enshi 445000, China |
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Abstract Objective: To study the effect of video-assisted thoracoscopy and thoracotomy on the treatment of non-small cell lung cancer and the changes of serum transforming growth factor (TGF- alpha) and cytokeratin 19 fragment (CA21-1). Methods:80 patients of hypertension with diabetes mellitus who received therapy from February 2016 to February 2017 in our hospital were selected as research objects. According to the According to ballot method divided into observation group(n=40) and control group(n=40). The observation group was treated with video-assisted thoracoscopic lobectomy,The control group was treated with conventional thoracotomy for lobectomy.Then the operation time, the amount of bleeding, the time of drainage, the clearance of lymph nodes, the operation indexes of the time of hospitalization, the VAS score, the adverse reaction, and the therapeutic effect in two groups were compared.Results:The intraoperative blood loss, drainage time and hospital stay in the observation group were significantly lower than those in the control group[(209.63±17.92)ml vs(321.42±19.36)ml,(4.80±1.20)d vs(6.97±1.72)d,(6.37±1.02)d vs(11.96±2.39)d](P<0.05);The VAS score was significantly lower than that of the control group [(1.01±0.30)score vs(2.34±0.52)score](P<0.05);The level of TGF- alpha and CA21-1 was significantly lower than that of the control group[(11.53±2.60)μg/L vs(20.69±3.86)μg/L,(3.18±0.52)μg/L vs(6.97±0.72)μg/L](P<0.05);The total incidence of adverse reactions was significantly lower than that of the control group [7.50% (3/40) vs42.86%(18/42)](P<0.05). Conclusions: Compared with video-assisted thoracoscopy and thoracotomy in the treatment of non-small cell lung cancer, video-assisted thoracoscopy is more effective.It can alleviate complications and postoperative pain, regulate immune function and reduce serum levels of TGF-alpha and CA21-1. It is beneficial to the prognosis of patients. It is better than conventional thoracotomy and can achieve satisfactory clinical efficacy.
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2018, Vol. 24 
