先天性心脏病术后急性肾损伤患儿尿NGAL KIM-1表达分析

doi:10.3969/j.issn.1006-6233.2018.10.010

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Abstract Objective: To investigate the expression characteristics of urine neutrophil gelatinase associated apolipoprotein (NGAL) and Kidney Injury Molecule-1 (KIM-1) in children with acute kidney injury (AKI) after congenital heart surgery. Methods:160 cases children with congenital heart disease undergoing surgical treatment included in the study from April 2014 to March 2017 were divided into AKI group and N-AKI group according to whether the postoperative acute kidney injury, (61 cases and 99 cases respectively).And 60 healthy children were selected as healthy group during the same period.The levels of urinary NGAL and KIM-1 in 3 groups were detected at different time points. Results: ①The baseline urinary NGAL levels in AKI group, AKI-free group and healthy group were (9.52+1.26), (9.45+1.33), (9.48+1.30) ng/mL, respectively, with no significant difference (P > 0.05). At 6h, 12h, 24h and 48h after operation, the levels of NGAL in AKI group were (25.17 [8.72], (40.14 [16.52], (31.17 [10.64], (30.54 [11.50] ng / mL, respectively, while those in AKI group were (10.29 [3.13, (13.05 [3.25, (11.39 [2.77, (10.65 [3.05] ng / mL, respectively. There was significant difference in urinary NGAL levels between AKI group and non-AKI group at 6 hours after operation (F_group= 31.315, P<0.05). The urinary NGAL levels of the two groups increased first and then decreased with the prolongation of time (F_time= 21.073, P<0.05). The increase in AKI group was greater than that of the control group (F_interaction= 17.746, P<0.05). ② The baseline levels of urinary KIM-1 in AKI group, N-AKI group and healthy group were(281.63±24.77), (279.07±25.01),(280.48±23.80)ng/L, respectively, with no statistical difference (P>0.05); The levels of urinary KIM-1 in AKI group were (313.17±35.46),(496.16±35.21),(613.17±43.19), (582.33±37.13) at postoperative 6h, 12h, 24h and 48H, respectively, and those of N-AKI group were (290.69±26.14),(294.75±27.50),(286.32±23.34),(283.29±21.81)ng/L. There was significantly difference of urinary KIM-1 in these two groups (F_group=34.827,P<0.05), and were showed a inclined trend over time (F_time=25.031,P<0.05), the changed amplitude in AKI group was higher than N-AKI group (F_interaction=23.847,P<0.05). Conclusion: Urinary NGAL and KIM-1 levels in children with congenital heart disease were similar to those in normal children; both indicators were increased after surgery, but the incidence of AKI was more significant, which could be used for early diagnosis of AKI in children with congenital heart disease.

Key words： Children congenital heart disease Acute kidney injury Neutrophil gelatinase associated lipocalin Kidney injury-1

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	WANG Jing

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WANG Jing. Analysis of Urinary NGAL and KIM-1 Expression in Children with Acute Kidney Injury after Congenital Heart Surgery[J]. HeBei Med, 2018, 24(10): 1623-1626.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2018.10.010 OR http://www.hbyxzzs.cn/EN/Y2018/V24/I10/1623

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