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Effects of Tacrolimus combined with Huaiqihuang Granule on Primary Nephrotic Syndrome in Children and its Influence on Serum VEGF TGF-β1 IL-1β and IFN-γ |
ZHOU Wubin |
Huangshi Central Hospital, Hubei Huangshi 435000, China |
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Abstract Objective: To study the efficacy of tacrolimus combined with Huaiqihuang granule in children with primary nephrotic syndrome and the effects of serum vascular endothelial growth factor (VEGF), transforming growth factor-β1 (TGF-β1), interleukin 1β (IL-1β), interferon-γ (IFN-γ). Methods: From September 2016 to March 2017, 80 children with primary nephrotic syndrome were selected and divided into control group and experimental group, 40 cases in each group. On the basis of routine treatment, the control group was treated with tacrolimus, and the experimental group was treated with tacrolimus combined with Huaiqi Huang granules for 12 weeks. The clinical efficacy, serum levels of VEGF, TGF-beta 1, IL-1beta, IFN-gamma and adverse reactions were observed and compared between the two groups. Results: At the 4th week, the time of edema subsided and urinary protein was shorter than that of the control group, the difference was statistically significant (P <0.05). The blood cholesterol level of the experimental group was slightly higher than that of the control group (P <0.05). At the 12th week, the effective rate of the experimental group was 95.00%, which was higher than that of the control group (77.50%). The level of serum albumin in the experimental group was significantly higher than that in the control group (P<0.05). The level of serum albumin was slightly higher than that of the control group, the difference was not statistically significant (P>0.05). Before treatment, the levels of serum VEGF, TGF-β1, IL-1β and IFN-γ were not statistically significant (P>0.05). After treatment, the levels of serum VEGF, TGF-β1, IL-1β and IFN-γ were decreased in both groups (P<0.05). The difference between the two groups was significant (P<0.05). The total adverse reaction rate was 15.00% in the experimental group, which was lower than that in the control group, of which was 35.00% (P <0.05). Conclusion: The clinical effect of tacrolimus combined with Huaiqihuang granule in the treatment of children with primary nephrotic syndrome is better, which can effectively reduce the serum levels of VEGF, TGF-β1, IL-1β, IFN-γ level.
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[1] 张良,李志辉,银燕,等.儿童初发IgA肾病肾病综合征型的临床特点[J].中国当代儿科杂志,2015,17(8):786~791. [2] 王永霞.儿童原发性肾病综合征临床特征分析[J].中国卫生标准管理,2016,7(11):50~52. [3] 耿海云,曹力,王薇,等.槐杞黄颗粒治疗儿童原发性肾病综合征的前瞻性随机对照临床研究[J].中国当代儿科杂志,2015,17(1):31~34. [4] 中华医学会儿科学分会肾脏学组.儿童激素敏感、复发/依赖肾病综合征诊治循证指南(2016)[J].中华儿科杂志,2017,55(10):729~734 [5] 刘俊朝,俞建,时毓民.肾病综合征患儿免疫功能的变化[J].中国中西医结合儿科学,2014,6(1):28~31. [6] 白丽春,覃远汉.免疫抑制剂在儿童难治性肾病综合征中的应用新进展[J].重庆医学,2015,44(19):2681~2684. [7] 汪年松,桂定坤,李军辉.他克莫司在肾脏病中的合理应用[J].中华肾病研究电子杂志,2014,3(4):200~203. [8] 张宏文,肖慧捷,姚勇.他克莫司治疗小儿肾病综合征致急性肾衰竭3例报告[J].临床儿科杂志,2017,35(6):409~411. [9] 刘运广,曹珊,林娜,等.槐杞黄颗粒联合泼尼松治疗儿童原发性肾病综合征疗效及对免疫功能影响的前瞻性随机对照研究[J].右江民族医学院学报,2017,39(3):163~167. [10] 钱古柃,赵镭,刘爱民.槐杞黄颗粒辅助治疗儿童肾病综合征的疗效观察[J].中草药,2014,45(16):2375~2377. |
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