临床药师指导下非瓣膜病房颤患者应用华法林抗凝治疗的疗效分析

doi:10.3969/j.issn.1006-6233.2018.08.047

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Abstract Objective: To analyze the efficacy of warfarin anticoagulation therapy in patients with non valvular atrial fibrillation under the guidance of clinical pharmacists. Methods: 91 patients with non-valvular atrial fibrillation who received therapy from January 2014 to June 2017 in our hospital, according to different treatment methods. All the patients were divided into 47 control groups and 44 research groups. The control group was treated with traditional warfarin, and the research group was given warfarin under the guidance of clinical pharmacist. then treatment compliance, international standardized ratio (INR), endothelial function, fibrinolytic index, and adverse reactions between two group was compared. Results: After treatment, the therapeutic compliance in the research group was better than that of the control group, with statistically significant difference (P<0.05). the INR compliance rate in research group was higher than the control group (P<0.05). Before treatment,the endothelin 1 (ET-1), circulating endothelial cells (CEC) in two group was no difference (P>0.05), after treatment, the above indicators in research group was lower than the control group, with statistically significant difference (P<0.05). plasminogen activator inhibitor-1 (PAI-1), tissue plasminogen activator (t-PA) and D-dimer (D-D) in research group were lower than the control group (P<0.05). Complication rate in research group was lower than that in the control group (P<0.05). Conclusion: Non-valvular AF patients with clinical pharmacist guidance warfarin anticoagulant therapy can change the patient's cognitive and behavioral status, improve their treatment compliance and INR compliance rate, reduce the risk of warfarin anticoagulation.

Key words： Non-valvular atrial fibrillation Warfarin anticoagulation Clinical pharmacist guidance

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2018.08.047 OR http://www.hbyxzzs.cn/EN/Y2018/V24/I8/1404

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