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| Effect of Nimodipine Combined with Donepezil Hydrochloride on Cognitive Impairment and Quality of Life in Patients with Cerebral Infarction |
| WANG Jianfeng, ZHANG Chenhong, WANG Wan, et al |
| No.215 Hospital of Shaanxi Nuclear Industry, Shaanxi Xianyang 712000, China |
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Abstract Objective: To study the effect of Nimodipine combined with donepezil hydrochloride on cognitive impairment and quality of life in patients with cerebral infarction. Methods: 82 patients of cognitive impairment after cerebral infarction who received therapy from Jan. 2016 to Dec. 2016 in our hospital were selected. According to random number table, The patients were divided into the observation group and the control group, 41 cases of each group. Patients in the control group were treated with donepezil hydrochloride, and patients in the observation group were treated with nimodipine on this basis. The clinical efficacy and NIHSS score, Montreal Cognitive Assessment Scale (MoCA) score, motor function scale (Fugl-meyer score) and adverse reactions were compared between the two groups before and after treatment. Results: After treatment, the clinical efficiency of the observation group was significantly higher than that of the control group 92.68%(38/41) vs 73.17% (30/41) (P<0.05); The NIHSS score in observation group was significantly lower than that in control group (3.87±1.33) vs (5.56±1.85) score (P<0.05); The MoCA score in observation group was significantly higher than that in control group (26.53±5.71) vs (22.02±5.47) score (P<0.05); The Fugl-meyer score in observation group was significantly higher than that in control group (84.57±6.13) vs (73.13±6.02) score (P<0.05); The total incidence of adverse reactions in observation group was lower than that in control group 14.63% (6/41) vs 41.46% (17/41) (P<0.05). Conclusion: Nimodipine combined with donepezil hydrochloride is effective in the treatment of cognitive impairment of cerebral infarction. It can obviously improve the nerve defect, cognitive function and motor function of the patients, and improve the quality of life of the patients with high safety. The effect is better than the use of donepezil alone. It is worthy of application.
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[1] 陈思,陆斌,尹文伟,等.参芪扶正注射液联合尼莫地平对脑梗死恢复期患者血液指标的影响[J].中国药房,2016,27(5):683~685.
[2] 钟艺华,唐显军,南映瑜.尼莫地平联合奥拉西坦胶囊治疗T2DM患者合并轻度血管性认知障碍的疗效观察[J].重庆医学,2014,43(35):4737~4739.
[3] Moran JM, Pedrera-Zamorano JD. Comments on "Efficacy and safety assessment of acupuncture and nimodipine to treat mild cognitive impairment after cerebral infarction: a randomized controlled trial"[J]. BMC Complement Altern Med,2017, 17(1):119.
[4] 刘素勤.盐酸美金刚联合盐酸多奈哌齐对帕金森痴呆患者认知功能及日常生活能力的影响[J].中国地方病防治杂志,2016,31(12):1410.
[5] Devanand DP, Lentz C, Chunga RE,et al. Change in odor identification impairment is associated with improvement with cholinesterase inhibitor treatment in mild cognitive impairment[J].Alzheimers Dis,2017,60(4):1525~1531.
[6] 中华医学会神经病学分会脑血管病学组急性缺血性脑卒中诊治指南撰写组.中国急性缺血性脑卒中诊治指南2010[J].中国全科医学,2011,14(35):4013~4017.
[7] 中国卒中学会,卒中后认知障碍管理专家委员会.卒中后认知障碍管理专家共识[J].中国卒中杂志,2017,6(12):519~531.
[8] 安晓雷,郭靖,李传玲,等.尼莫地平联合丁苯肽在预防急性脑梗死后血管性认知障碍中的作用[J].中风与神经疾病杂志,2016,33(3):267~268.
[9] 王翊飞,张李涛,褚正民,等.前列地尔注射液联合尼莫地平注射液治疗动脉瘤性蛛网膜下腔出血伴脑血管痉挛的临床研究[J].中国临床药理学杂志,2016,32(21):1942~1945,1949.
[10] Petersen RC, Thomas RG, Aisen PS,et al. Randomized controlled trials in mild cognitive impairment: Sources of variability[J]. Neurology,2017,88(18):1751~1758.
[11] Li L, Xu S, Liu L, et al. Multifunctional compound AD-35 improves cognitive impairment and attenuates the production of TNF-α and IL-1β in an Aβ25-35-induced rat model of alzheimer's disease[J].Alzheimers Dis,2017,56(4):1403~1417.
[12] 任志军,李粮,王丹.盐酸多奈哌齐治疗急性脑梗死的临床研究[J].实用医学杂志,2014,30(16):2648~2649.
[13] 白银,王淑贞,郭洪志,等.盐酸多奈哌齐治疗轻、中度阿尔茨海默病患者临床疗效及血清炎性介质水平变化的动态观察[J].中国老年学杂志,2016,36(8):1871~1873. |
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2018, Vol. 24 
