同型半胱氨酸糖化血红蛋白神经胶质纤维酸性蛋白在急性缺血性卒患者中的表达及意义

doi:10.3969/j.issn.1006-6233.2018.08.008

Abstract
Figure/Table
References
Related Citation (15)

Download: PDF (1341 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective: To study the expression and significance of homocysteine (Hcy), glycosylated hemoglobin (HbAlc), glial fibrillary acidic protein (GFAP) in acute ischemic stroke patients. Methods: 80 patients of acute ischemic stroke received therapy from Oct. 2015 to Oct. 2016 in our hospital were selected as observation group, in the same period, 80 healthy people who received medical examination in our hospital were selected as the control group. Enzyme linked immunosorbent assay (ELISA) was used to detect the expression of Hcy, HbAlc and GFAP in all subjects, the expression of Hcy, HbAlc and GFAP in patients with acute ischemic stroke with different infarct level, different severity of disease and different prognosis were compared, and the relationship between Hcy, HbAlc, GFAP and acute ischemic stroke was analyzed. Results: The Hcy, HbAlc and GFAP in the observation group were significantly higher than those in the control group (P<0.05); the expression of Hcy, HbAlc and GFAP increased with the increase of infarct size and the severity of the disease, and the difference was significantly different (P<0.05); the Hcy, HbAlc and GFAP in the poor prognosis group were significantly higher than those in the good prognosis group (P<0.05); the Pearson correlation analysis showed that there was a positive correlation between Hcy, HbAlc, GFAP and the degree of National Institutes of Health Stroke Scale (NIHSS) scores and the area of cerebral infarction (P<0.05); and in Logistic regression, Hcy, HbAlc, and GFAP are all risk factors affecting the prognosis of patients with acute ischemic stroke (P<0.05). Conclusion: Hcy, HbAlc and GFAP are independent risk factors that affect the degree and prognosis of acute ischemic stroke, it can be used as an important indicator of diagnosis, treatment and evaluation of the disease, and it is of high value in clinical application.

Key words： Acute ischemic stroke Nerve function Homocysteine Glycosylated hemoglobin Glial fibrillary acidic protein

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	ZHANG Nan
	JIA Yonghua
	JI Qiling
	et al

Cite this article:

ZHANG Nan,JIA Yonghua,JI Qiling, et al. Expression and Significance of Homocysteine Glycosylated Hemoglobin and Glial Fibrillary Acidic Protein in Patients with Acute Ischemic Stroke[J]. HeBei Med, 2018, 24(8): 1261-1265.

URL:

http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2018.08.008 OR http://www.hbyxzzs.cn/EN/Y2018/V24/I8/1261

[1] 曹承兰,余年,林兴建,等.脑卒中高危人群的相关危险因素[J].临床神经病学杂志,2014,27(5):335~337.
[2] Banecka-Majkutewicz Z, Kadziński L, Grabowski M, et al. Evidence for interactions between homocysteine and genistein: insights into stroke risk and potential treatment[J]. Metab Brain Dis, 2017, 32(6): 1855~1860.
[3] Olaiya MT, Cadilhac DA, Kim J, et al. Community-based intervention to improve cardiometabolic targets in patients with stroke: a randomized controlled trial[J]. Stroke, 2017, 48(9): 2504~2510.
[4] 倪亚珺,叶志弘.中国人群2型糖尿病患者并发脑卒中危险因素的Meta分析[J].护理与康复,2016,15(11):1026~1033.
[5] Vietheer JM, Rieger J, Wagner M, et al. Serum concentrations of glial fibrillary acidic protein (GFAP) do not indicate tumor recurrence in patients with glioblastoma[J].Neurooncol, 2017, 135(1): 193~199.
[6] 中华医学会神经病学分会,中华医学会神经病学分会脑血管病学组.中国急性缺血性脑卒中诊治指南2014[J].中华神经科杂志,2015,48(4):246~257.
[7] 蔡业峰,贾真,张新春,等.美国国立卫生院卒中量表(NIHSS)中文版多中心测评研究--附537例缺血中风多中心多时点临床测评研究[J].北京中医药大学学报,2008,31(7):494~498.
[8] McArthur K, Fan Y, Pei Z, et al. Optimising outcome assessment to improve quality and efficiency of stroke trials[J]. Expert Rev Pharmacoecon. Outcomes Res, 2014, 14(1): 101~111
[9] 王萍,韩耀风,赵天予,等.中国人群脑卒中发病影响因素Meta分析[J].现代预防医学,2016,43(16):2893~2896.
[10] Cloonan L, Fitzpatrick KM, Kanakis AS, et al. Metabolic determinants of white matter hyperintensity burden in patients with ischemic stroke[J]. Atherosclerosis, 2015, 240(1): 149~153.
[11] Lehmann MF, Kallaur AP, Oliveira SR, et al. Inflammatory and metabolic markers and short-time outcome in patients with acute ischemic stroke in relation to TOAST subtypes[J]. Metab Brain Dis, 2015, 30(6): 1417~1428.
[12] Shin SB, Kim TU, Hyun JK, et al. The Prediction of Clinical Outcome Using HbA1c in Acute Ischemic Stroke of the Deep Branch of Middle Cerebral Artery[J]. Ann Rehabil Med, 2015, 39(6): 1011~1017.
[13] 郭双喜,马安娜,史莉瑾.糖化血红蛋白水平与急性缺血性脑卒中患者神经功能缺损及预后的关系[J].山东医药,2014,54(8):32~34.
[14] Dos Santos JPA, Vizuete A, Hansen F, et al. Early and persistent o-GlcNAc protein modification in the streptozotocin model of alzheimer's disease[J].Alzheimers Dis, 2018, 61(1): 237~249.
[15] Zhang J, Zhang CH, Lin XL, et al. Serum glial fibrillary acidic protein as a biomarker for differentiating intracerebral hemorrhage and ischemic stroke in patients with symptoms of acute stroke: a systematic review and meta-analysis[J]. Neurol Sci, 2013, 34(11): 1887~1892.