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| Clinical Study of Serum 25-hydroxyvitamin D level and Inflammatory Factors and Nutritional Status in Continuous Ambulatory Peritoneal Dialysis Patients |
| LI Xuena, HU Guicai |
| The Affiliated Hospital of Chengde Medical, Hebei Chengde 067000, China |
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Abstract Objective: To evaluate the association between 25-hydroxyvitamin D level and inflammatory and nutritional factors in continuous ambulatory peritoneal dialysis. Methods: Serum levels of 25-hydroxyvitamin D, albumin, prealbumin, neutrophi-lymphocyte ratio(NLR),high-sensitivity-reactive protein (Hs-CRP),IL-6,and TNF-a were measured in 89 patients with continuous peritoneal dialysis.All the patients were divided into there groups according to the serum 25-hydroxyvitamin D level. Vitamin D normal: 25(OH)D＞30ng/ml,Vitamin D insufficiency: 16<25(OH)D≤30ng/ml,Vitamin D deficiency: 25(OH)D≤15ng/ml,Inflammatory factory and nutritive index were compared among the three groups. Result: The average of serum 25 (OH) D level was 5.0~41.2ng/ml in patients with continuous peritoneal dialysis, the prevalence of 25 (OH) D deficiency was 86.51%. The levels of Hs-CRP, IL-6, TNF-a, and NLR were obviously lower in 25 (OH) D normal group than deficiency and insufficiency group, albumin and prealbumin were higher than patients with vitamin D deficiency and insufficiency groups.the difference was statistically significant(P<0.001). Conclusion: The level of blood 25 (OH) D in continuous ambulatory peritoneal dialysis patients plays an important role in micro inflammatory state and malnutrition.
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2018, Vol. 24 
