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Effects of Enoxaparin Combined with Ulinastatin on the Thrombogenesis and Serum RANKL, OPG and MMP-9 Levels of Patients after Knee Arthroplasty |
PENG Xiong, CHEN Jialian |
Hanchuan People's Hospital, Hubei Hanchuan 431600, China |
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Abstract Objective: To study the effect of enoxaparin combined with ulinastatin on the thrombus prophylaxis and the serum factor-1 receptor activator ligand (RANKL), osteoprotegerin (OPG), matrix metalloproteinase -9 (MMP-9) levels of patients after knee arthroplasty. Methods: From July 2015 to June 2016, 80 patients with knee replacement were included in this study in our hospital, and divided into the observation group and control group according to the admission order with 43 cases in each group. The control group was treated with enoxaparin sodium for injection on the basis of knee arthroplasty. The observation group was treated with ulinastatin on the basis of control group. The changes of serum PANKL, OPG, MMP-9 levels, coagulation function indexes before and after treatment, postoperative thrombosis and the incidence of adverse reactions were compared between the two groups. Results: The levels of serum PANKL, OPG and MMP-9 in the two groups after treatment were significantly lower than those before operation (P <0.05). Compared with the control group, the serum PANKL level in the observation group was higher (P <0.05), the serum OPG and MMP-9 levels were lower (P <0.05). There was no significant difference in the D-dimer, platelet, partial thromboplastin time, calf muscle vein thrombosis, deep vein thrombosis and thrombosis length between the two groups (P> 0.05). The proportion of thrombus, the total length of the thrombus, the number of thrombosis in the observation group were significantly lower than those of the control group (P<0.05). The was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: Enoxaparin combined with ulinastatin can effectively prevent the thrombogenesis of lower extremities after knee arthroplasty, which can effectively reduce the serum levels of PANKL, OPG and MMP-9 with high safety.
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[1] 陈小妹,林惠武.不同镇痛方法对膝关节置换术患者术后疼痛及膝关节功能恢复的影响[J].中国医院药学杂志,2017,37(6):530~532. [2] 陈俊南,PRANESH Kumar Yadav,唐赢,等.利伐沙班和依诺肝素预防人工膝关节置换术后下肢深静脉血栓的临床研究[J].中国临床药理学杂志,2016,32(2):108~110. [3] 唐帅,齐振红,刘硕,等.乌司他丁对双侧全膝关节置换术后凝血功能和下肢深静脉血栓形成的影响[J].临床麻醉学杂志,2014,30(4):333~335. [4] 杨勇,赵良虎,黄金.膝关节置换术结合中药疗法对膝关节骨性关节炎的临床疗效研究[J].中国骨质疏松杂志,2016,22(7):837~841. [5] 杨帆,张庆猛,李恒,等.个性化截骨技术在全膝关节置换术中临床应用和疗效分析[J].中国矫形外科杂志,2015,23(17):1571~1575. [6] 魏志辉,张铭华,赵波,等.不同剂量利伐沙班与依诺肝素预防全髋关节置换后静脉血栓形成:安全及有效性的Meta分析[J].中国组织工程研究,2016,20(53):8022~8031. [7] 陆慧杰,庄汝杰,陈之青.利伐沙班对比依诺肝素预防骨科大手术后深静脉血栓形成的疗效与安全性评价[J].中国临床药理学杂志,2015,31(9):693~695. [8] 唐帅,徐仲煌,刘硕,等.乌司他丁对膝关节置换术后肝功能的影响[J].中国医学科学院学报,2014,36(5):526~529. [9] 万伏银,郭万首,张启栋,等.骨蜡在全膝关节置换术中止血作用的有效性和安全性评价[J].中国矫形外科杂志,2015,23(17):1576~1580. [10] 唐帅,徐仲煌,杨宏,等.乌司他丁对双侧全膝关节置换术后患者炎性反应和急慢性疼痛的影响[J].基础医学与临床,2014,34(4):514~518. |
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