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| Value of Endocrine Hormone Levels in Evaluating the Effects of Surgical Treatment for Patients with Functional Pituitary Adenoma |
| TANG Guangrong, FAN Chaofeng, DAI Heling |
| West China Hospital of Sichuan University, Sichuan Chengdu 610041, China |
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Abstract Objective: To investigate the value of changes of endocrine hormone levels in evaluating the effects of surgical treatment for patients with functional pituitary adenoma. Methods: According to the degree of surgical resection, 500 patients with functional pituitary adenoma, including 273 patients with prolactin (PRL) type and 227 patients with growth hormone (GH) type were divided into the total resection group and the partial resection group. Serum levels of PRL and GH were determined before surgery, at 1 day, 3 days and 7 days after surgery. Above-mentioned indexes were compared between the total resection group and the partial resection group. The tumor control was evaluated during follow-up, and the value of PRL and GH in predicting the surgical effects on PRL type and GH type pituitary adenomas was analyzed by the receiver operating characteristic (ROC) curve. Results: Serum levels of PRL and GH in the total resection group at 1 day, 3 days and 7 days after surgery were significantly lower than those in the partial resection group (P<0.05). CT or MRI reexamination showed that the tumor control rates of patients with PRL type pituitary adenoma treated by total resection and patients not treated by total resection were 97.00% and 31.51% respectively. The tumor control rates of patients with GH type pituitary adenoma treated by total resection and patients not treated by total resection were 85.54% and 54.10%, respectively. The area under the curve (AUC), sensitivity and specificity of postoperative serum PRL in predicting the 2-year tumor control rate of patients with PRL type pituitary adenomas were 0.899, 78.52% and 88.10%, respectively. The optimal critical value, AUC, sensitivity and specificity of serum GH in predicting the 2-year tumor control rate of patients with GH type pituitary adenomas were 1.00nmol/L, 0.900, 79.00% and 88.14%, respectively. Conclusion: The monitoring of serum PRL and GH levels after operation has a certain predictive value for the degree of surgical excision and recurrence of PRL and GH pituitary adenomas.
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2018, Vol. 24 
