|
|
|
| Shuanghua Qingre Granules Combined with Ambroxol Hydrochloride in the Treatment of Geratic Chronic Tracheitis and Effects on the Serum IL-6 IL-17 TNF-α MMP-9 levels |
| CHEN Lulu, et al |
| Qingdao Central Hospital, Shandong Qingdao 266042, China |
|
|
|
|
Abstract Objective: To study the curative efficacy of Shuanghua Qingre granules combined with ambroxol hydrochloride in the treatment of geratic chronic tracheitis and its effects on the serum interleukin-6(IL-6), interleukin-17 (IL-17), tumor necrosis factor-α(TNF-α) and matrix metalloproteinase-9(MMP-9) levels. Methods: 80 patients of geratic chronic tracheitis admitted from April 2014 to April 2015 in our hospital were selected as research objects and divided into the observation group (n=40) and the control group (n=40). Both groups of patients were treated with conventional treatment after admission, including asthma, spasmolysis, fever etc. The control group was treated with ambroxol hydrochloride injection on the basis of conventional therapy, every time 30mg, 2 times a day, while the observation group was treated with Shuanghua Qingre granules on the basis of control group, once for 20g, 3 times a day. Both groups were treated for 2 weeks. Then the curative effect, clinical symptoms (cough, wheezing, dyspnea) disappearance time, changes of IL-6, IL-17, TNF-α, MMP-9 levels, pulmonary function FEV1, FEV1/FVC before and after treatment were compared between two groups. Results: The total effective rate of observation group was significantly higher than that of the control group [95.00% (38/40) vs 75.00% (30/40)] (P<0.05); The disappearance time of cough, wheezing, breathing difficulties were significantly shorter in the observation group than those of the control group [(2.80±0.67)d vs (5.38±1.20)d, (4.58±1.01)d vs (8.93±1.21)d (4.02±0.90)d vs (6.78±1.35)d] (P<0.05); the serum IL-6, IL-17, TNF-α, MMP-9 levels were significantly lower than those of the control group [(8.02±2.12)μg/L vs (12.32±2.30)μg/L, (15.87±3.42)pg/L vs(19.36±4.02)pg/L, (16.30±4.21)ng/L vs (23.76±4.60)ng/L, (0.30±0.12)ng/L vs (0.50±0.14)ng/L] (P<0.05); the FEV1,FEV1/FVC were significantly higher than those of the control group [(57.36±9.32)% vs (50.37±8.97)%,(66.86±7.80)% vs (61.92±6.84)%] (P<0.05). Conclusion: Effect of Shuanghua Qingre granule combined with ambroxol hydrochloride in treatment of senile chronic bronchitis is significantly better than the treatment with single, ambroxol hydrochloride injection. It can significantly improve the clinical symptoms and lung function of the patients, and reduce the level of serum IL-6, IL-17, TNF-α and MMP-9.
|
|
|
|
|
|
[1] 孙丹,杨硕,吴瑕,等.盐酸氨溴索雾化吸入疗法治疗老年慢性支气管炎临床疗效的研究[J].中国临床药理学杂志,2015,31(2):86~88.
[2] 曹静.老年慢性支气管炎临床治疗观察[J].中外医学研究,2015,13(27):131~133.
[3] 孙平平,曲书强.毛细支气管炎的研究进展[J].临床肺科杂志,2014,19(7):1312~1314.
[4] 梁德坚,汤建伟,袁鸣凤.多索茶碱联合氨溴索治疗急性发作期慢性支气管炎疗效及对肺功能、炎症因子水平的影响[J].泰山医学院学报,2017,38(12):1380~1382.
[5] 王大飞.老年慢性支气管炎的中医治疗临床研究[J].光明中医,2015,30(11):2355~2356.
[6] 李鲁.盐酸氨溴索联合中药治疗老年慢性支气管炎的临床价值研究[J].中国医学前沿杂志(电子版),2014,6(6):155~157.
[7] 童波.盐酸氨溴索辅助治疗慢性支气管炎的临床疗效观察[J].当代医学,2015,21(35):138~139.
[8] 王秀兰,成佳黛.双花清热颗粒治疗慢性支气管炎急性发作(痰热郁肺证)的临床观察[J].中华中医药杂志,2016,31(6):2427~2429.
[9] 洪克付.盐酸氨溴索辅助治疗慢性支气管炎的药效评价[J].临床肺科杂志,2013,18(5):868~869.
[10] 顾克辉,王民瑞,王玉兰,等.常规西药联合沙参麦冬汤加减治疗慢性支气管炎患者的疗效及对炎症因子的影响[J].内科,2017,12(5):632~634. |
|
|
|
2018, Vol. 24 
