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| Expression and Significance of Integrin α2β1 Protein and CD44V3 Protein in Cervical Squamous cell Carcinoma |
| ZHAO Yaohong, QI Zhiyu, GUO Dongxia, et al |
| Chengde Maternal and Chile Health Hospital, Hebei Chengde 067000, China |
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Abstract Objective: To investigate the expression and clinical significance of integrin α2β1 protein and CD44V3 protein in cervical squamous cell carcinoma. Methods: Expression protein of integrinα2β1 and CD44V3 were detected in 80 cases of cervicals quamous cell carcinoma and normal cervical tissues 50 cases by SP method of immunohistochemistry. The correlation between the expression of two indexes in cervical squamous cell carcinoma and the relationship with the biological behavior of cervical squamous cell carcinoma were investigated. Result: The positive expression rates of integrin alpha 2 beta 1 protein and CD44V3 protein in cervical squamous cell carcinoma were 73.4% and 71.3%, respectively, which were all higher than those in normal cervical mucosa tissues, and the difference was statistically significant (P < 0.05). Integrin alpha 2 beta 1 protein and CD44V3 protein were significantly related to the degree of differentiation, clinical stage, lymph node metastasis and depth of invasion of cervical squamous cell carcinoma. The expression of integrin alpha 2 beta 1 protein and CD44V3 protein in the squamous cell carcinoma of the cervix was positively correlated (R =0.67). Conclusion: Expression of integrinα2β1 and CD44V3 protein may play an important role in the occurrence and development of cervical squamous cell carcinoma. They have positive synergy, and be used as a judgment of local invasion, distant metastasis and prognosis prediction factors of cervical squamous cell carcinoma.
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2018, Vol. 24 
