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| Foxiangyin on the Model Rats with Cold Coagulation and Blood Stasis Dysmenorrhea Pain Reaction and Blood Rheology |
| MIAO Xihong, FENG Xiaojing, et al |
| Chengde Central Hospital, Hebei Chengde 067000, China |
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Abstract Objective: To investigate the effects of water extract from Foxiang Yin (FXY) on pain reaction and hemorheological parameters of rats with dysmenorrhe induced by cold coagulation and blood stasis to provide the experimental basis for clinical application of the prescription. Methods: The rats dysmenorrhea model induced by cold congealing and blood stasis were made by ice water bath and subcutaneous injection of adrenaline hydrochloride(Adr)combined with intraperitoneal injection of oxytocin. The inhibition rate of pain reaction was were calculated. The prothrombin time (PT), thrombin time (TT), activated partial thromboplastin time (APTT), the rate of platelet aggregation, hematocrit (HCT), K value of erythrocyte sedimentation equation, plasma viscosity and whole blood viscosity were detected. Results: The CT,PT,TT and APTT in 1.8g/kg,3.6g/kg and 7.2g/kg doses groups of FXY are significantly longer than that in the model control group(P<0.05 or P＜0.01). The platelet aggregation rate in high and middle 3.6g/kg and 7.2g/kg dose of FXY group were significantly lower than that of model group (P<0.05 or P＜0.01). The hematocrit ( HCT) and ESR equation K values in all doses of FXY groups were significantly lower than that of model group (P<0.05). The plasma viscosity and whole blood viscosity in all dosage of FXY groups were lower than that of model group (P<0.05 or< P 0.01). Conclusion: FXY has obvious analgesic effect on the cold coagulation and blood stasis dysmenorrhea rats and improve high agglutination condition of blood and hemorheology is one of its action mechanisms.
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2017, Vol. 23 
