短期胰岛素强化治疗对2型糖尿病患者血糖长期控制的效果

doi:10.3969/j.issn.1006-6233.2017.10.034

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Abstract Objective: To investigate the effect of short term intensive insulin therapy on blood glucose in patients with type 2 diabetes. Methods: 120 cases of type 2 diabetic patients were Selected from January 2015 to December 2016 in Department of Endocrinology as the object of study. Patients were divided into control and observation group by stratified randomization, 60 cases in each group. Patients in the two groups were underwent diabetic education and diet, exercise therapy; Based on the routine therapy, patients in the control group were given metformin therapy; patients in the observation group were given islet hormone intensive therapy, such as subcutaneous injection Novolin R (short acting insulin ), three times daily, 30 minutes before meals and subcutaneous injections Novolin N (acting insulin)three times daily before bedtime. Based on the glycemic control to adjust the dose of insulin, continuous treatment for 1 month. Regular follow-up 3 months, fasting insulin (fins), insulin resistance index (HOMA-IR), fasting C peptide (fc-p), postprandial 2H C-peptide (2H C-P), postprandial 2 h insulin level (Hins)were compared between the two groups to assess islet beta cell function; Besides, fasting blood glucose (FBG), 2hPG (2 h postprandial blood glucose, glycosylated hemoglobin (HbA1c) level and the adverse reactions were also compared. Results: After treatment, fins, fc-p, 2h C-P, 2 Hins significantly increased that compared with before treatment, and higher significant increasing at observation group, the difference were statistically significant (P<0.05). After treatment, HOMA-IR level in patients of the two group was decreased that compared with before treatment, and more lower values was observed at observation group, the difference was statistically significant (P < 0.05). Before treatment, the levels of FBG, 2Hpg and HbA1c in patients of the two groups were not significantly different; While, they were significantly decreased and more lower values observed at observation group, the difference was statistically significant. There were no obvious heart, liver and kidney function damage in patients of the two groups and without obvious adverse reactions in the control group, only 1 patient appeared low blood sugar glucose. Conclusion: Short term intensive insulin therapy can improve islet beta cell function in patients with type 2 diabetes mellitus, and maintain the normal range of blood glucose, which is of clinical value.

Key words： Short term intensive insulin Type 2 diabetes mellitus Blood glucose control

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2017.10.034 OR http://www.hbyxzzs.cn/EN/Y2017/V23/I10/1699

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