男性2型糖尿病患者血尿酸与性激素相关性研究

doi:10.3969/j.issn.1006-6233.2017.08.021

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Abstract Objective: To observe the changes of blood sex hormone levels in male patients with type 2 diabetes, and to analyze the relationship between blood sex hormone levels and blood uric acid levels. Methods: 100 cases of male patients with type 2 diabetes in our hospital from February 2014 to January 2016 were selected as observation group, 110 healthy males in our hospital were selected as control group, and the levels of blood sex hormones were compared between the two groups, the general indexes, glucose metabolism indexes and sex hormone levels in observation group of patients with different levels of serum uric acid were compared. Results: The total serum testosterone level in the observation group was lower than that in the control group, while the levels of estradiol and SHBG in the observation group were higher than those in the control group, and the difference was statistically significant (P＜0.05); Compared with blood uric acid level in 159-251 mol/l group, the levels of FINS and PINS in blood uric acid level in 385-688 mol/l group were significantly increased, and the levels of total testosterone and SHBG were significantly lower, and the difference was statistically significant (P＜0.05). There was no significant difference in age, BMI, other glucose metabolism and sex hormones (P＞0.05). And there were no significant differences in age, BMI, glucose metabolism and sex hormones between the other groups (P＞0.05). Conclusion: In male patients with type 2 diabetes mellitus, there is a disorder of sex hormones such as testosterone, E2, SHBG, and low plasma SHBG levels are significantly correlated with the level of serum uric acid.

Key words： Male patients with type 2 diabetes mellitus Blood uric acid Sex hormones

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2017.08.021 OR http://www.hbyxzzs.cn/EN/Y2017/V23/I8/1307

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