盐酸右美托咪定在扁桃体切除术中的麻醉效果及对术后认知功能的影响研究

doi:10.3969/j.issn.1006-6233.2017.05.008

Abstract
Figure/Table
References
Related Citation (0)

Download: PDF (1402 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective: To analyze the anesthetic effect of dexmedetomidine hydrochloride in tonsillectomy and effect on postoperative cognitive function. Methods: 150 patients admitted to our hospital were treated with tonsillectomy as the study object from September 2013 to December 2016. According to the anesthesia method, all the patients were divided into experimental group (application of dexmedetomidine hydrochloride Anesthesia)and the control group(intravenous injection of saline), each group with 75 cases. The postoperative disturbances, cognitive differences of two groups were compared. Results: The recovery time of the patients in the experimental group were significantly shorter than those in the control group (P <0.05). The postoperative agitation score and postoperative disturbance rate were significantly lower in the experimental group than in the control group. The difference of cognitive function between the two groups was statistically significant (P<0.05) at 4 hours postoperatively and 1 day after operation. Conclusion: The anesthetic effect of dexmedetomidine hydrochloride in tonsillectomy significantly is obviously. It can effectively improve the patient's postoperative cognitive function score.

Key words： Dexmedetomidine hydrochloride Tonsillectomy Postoperative cognitive function

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	LEI Hengfa
	XIA Zhongyuan

Cite this article:

LEI Hengfa,XIA Zhongyuan. Anesthetic Effects of Dexmedetomidine Hydrochloride in Tonsillectomy and Influence on Postoperative Cognitive Function[J]. 河北医学, 2017, 23(5): 732-734.

URL:

http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2017.05.008 OR http://www.hbyxzzs.cn/EN/Y2017/V23/I5/732

[1] 刘玉杰,杜洪印.盐酸右美托咪定或丙泊酚复合芬太尼麻醉用于立体定向颅内血肿微创抽吸术治疗高血压脑出血的麻醉效果比较[J].上海医学,2012,35(12):1001~1004.
[2] 徐伟民,刘国庆.盐酸右美托咪定超前镇静对腹腔镜胆囊切除术老年患者应激反应的影响[J].中国老年学杂志,2013,33(2):309~312.
[3] 李建立,郭洪霞,梁巍,等.盐酸右美托咪定对丙泊酚诱导原代培养皮质神经元凋亡的影响[J].医药导报,2016,35(11):1164~1168.
[4] 莫坚,莫桂熙,刘亦君,等.盐酸右美托咪定对老年腹部手术患者术后认知功能障碍的影响[J].实用医学杂志,2012,28(24):4150~4152.
[5] 李鹏,陈丹丹,陈彰强,等.不同剂量盐酸右美托咪定对犬机械通气相关性肺损伤模型中炎性因子表达的影响[J].华中科技大学学报(医学版),2016,45(4):415~419.
[6] 张奕文,何忠承,石世坚,等.右美托咪定复合七氟烷全麻对老年患者术后早期认知功能的影响[J].广东医学,2012,33(14):2172~2174.
[7] 蒋鹏,黄祥君,赵明,等.盐酸右美托咪定对缺血-再灌注损伤大鼠心肌Toll样受体4/核因子-κB信号通路的作用[J].临床麻醉学杂志,2014,30(3):294~296.
[8] 赵伟新,刘静,宋慧钢,等.盐酸右美托咪定对老年患者全麻苏醒期拔管应激反应的影响[J].中国药房,2016,27(20):2807~2809.
[9] 陈盼,赵明,蒋鹏,等.盐酸右美托咪定预处理对缺血-再灌注损伤大鼠心肌Bax和Bcl-2表达的影响[J].重庆医学,2012,41(16):1604~1606,封3.
[10] 张沛,赵蕾,吴利娟,等.盐酸右美托咪定复合丙泊酚在老年患者无痛胃镜中的应用[J].中国老年学杂志,2014,11(9):2387~2389.
[11] Nour E M,Othman M M,Karrouf G I A,et al.Comparative evaluation of the epidural dexmedetomidine, ketamine or fentanyl in combination with bupivacaine in dogs[J].American Journal of Animal and Veterinary Sciences,2013,8(4):230~238.
[12] 唐华明,任羿.盐酸右美托咪定注射液与丙泊酚注射液在医学整形美容手术中镇静作用比较[J].中国医疗美容,2014,14(4):38~39,56.
[13] Candice R Preslaski,Scott W Mueller,Michael F Wempe et al.Stability of dexmedetomidine in polyvinyl chloride bags containing 0.9% sodium chloride injection[J].American journal of health-system pharmacy: AJHP,2013,70(15):1336~1341.
[14] Hasiuk, Michelle M M,Brown, Dean,et al.Application of fast-track surgery principles to evaluate effects of atipamezole on recovery and analgesia following ovariohysterectomy in cats anesthetized with dexmedetomidine-ketamine-hydromorphone[J].Journal of the American Veterinary Medical Association,2015,246(6):645~653.
[15] Lee J,Kim Y,Park C,et al.Comparison between dexmedetomidine and remifentanil for controlled hypotension and recovery in endoscopic sinus surgery[J].The Annals of Otology Rhinology and Laryngology,2013,122(7):421~426.