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| Effect of Interferon on Herpes Zoster and its Effect on Cellular Immune Function |
| WU Rile, REN Yu, YU Tao, et al |
| The First Hospital of Traditional Chinese and Western Medicine, Beijing 100026, China |
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Abstract Objective: To study the effects of interferon treatment of herpes zoster and its impact on cellular immune function in patients. Methods: 90 patients with herpes zoster treated in our hospital from December 2013 to December 2014 were randomly divided into observation group and control group, 45 cases in each. The control group was treated with valacyclovir therapy. The observation group was treated with interferon and valacyclovir therapy. The level of CD3,CD4 and CD8 were compared after 4 weeks, and pain relief time, blistering time, scab off time and crusting time were compared. The PNH rate of the two groups was compared after three monthes. Results: The total effective rate was 97.78% in the observation group patients, which were higher than 77.78% in the control group of patients, the difference was statistically significant (P <0.01). Pain relief time (2.24 ± 0.56) d, blistering time(1.56 ± 0.69) d, crusting time (4.58 ± 1.04) d and the scab off time (7.26 ± 1.48) d in the observation group of patients were shorter than pain relief time (5.69 ± 0.58) d, blistering time (3.02 ± 0.82) only d, crusting time (6.89 ± 1.07) d and the scab off time (13.65 ± 1.57) d in the control group of patients, a statistically significant difference (P <0.01). After treatment, CD3 levels (66.38 ± 7.62)× 10-2, CD4 levels (39.71 ± 7.55) × 10-2, CD8 levels (29.67 ± 7.23) × 10-2 and CD4 / CD8 levels (1.49 ± 0.16 ) × 10-2 CD3 levels in the observation group of patients were higher than CD3 levels(58.97 ± 8.36) × 10-2, CD4 levels (32.30 ± 7.69) × 10-2, CD8 levels (25.34 ± 7.22) × 10-2 and CD4 / CD8 levels (1.19 ± 0.14) × 10-2 in the control group of patients, the difference was statistically significant (P <0.01). Occur in patients with postherpetic neuralgia in the observation group was 6.67% lower than the 31.11% of patients in the observation group, the difference was statistically significant (P <0.01). Conclusion: Interferon treatment of herpes zoster can improve immune function in patients, and prevention of post-herpetic neuralgia patients
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2017, Vol. 23 
