中性粒细胞/淋巴细胞比值评估危重症患者预后的价值

doi:10.3969/j.issn.1006-6233.2017.04.007

Abstract
Figure/Table
References
Related Citation (3)

Download: PDF (1549 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective: To study the prognostic value of neutrophil-lymphocyte ratio (NLR) for predicting prognosis in critical ill patients. Methods: Adult patients who admitted our ICU from Jan. 2012 to Sep. 2013 and met inclusion criteria were included. NLR, PCT, APACHEII scores and SOFA scores according to the classification of different outcomes were compared. Univariate and multiple logistic regression analysis were used to identify potential independent risk factors for mortality. The performances of NLR in predicting mortality was assessed by receiver operating curves (ROC) and diagnostic parameters. The survival curves grouped by cut-off value of NLR were compared by using Kapla-Meier method. Results: Two hundred patients were included, among which 144 patients were male and the other 56 patients were female. According to classification of different outcomes, NLR in different groups had significant differences (P<0.05). NLR [1.10(1.04-1.16), p<0.001] and APACHEII scores [1.10(1.01-1.20), P<0.001] were the independent risk factors for mortality. The ROC of NLR for predicting mortality was 76.2% and the cut-off value was 4.92. Patients with NLR more than 4.92 had significantly lower survival rates than those with NLR less than 4.92 (P=0.002). Conclusion: NLR is an effective predictor of clinical outcomes in critical ill patients.

Key words： NLR Critical ill Mortality

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	LI Zhenjie
	PU Jun
	YUAN Hongbin

Cite this article:

LI Zhenjie,PU Jun,YUAN Hongbin. Prognostic Value of Neutrophil -lymphocyte Ratio in Critical ill Patients[J]. 河北医学, 2017, 23(4): 550-554.

URL:

http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2017.04.007 OR http://www.hbyxzzs.cn/EN/Y2017/V23/I4/550

[1] Zahorec R. Ratio of neutrophil to lymphocyte counts--rapid and simple parameter of systemic inflammation and stress in critically ill[J]. Bratisl Lek Listy,2001,102:5~14.
[2] 陈卫中, 潘晓平,宋兴勃,等.ROC曲线中最佳工作点的选择[J].中国卫生统计,2006,23:157~158.
[3] Jilma B, Blann A, Pernerstorfer T,et al. Regulation of adhesion moLecules during human endotoxemia. No acute effects of aspirin[J].Am Respir Crit Care Med,1999,159:857~863.
[4] Mahidhara R, Billiar TR. Apoptosis in sepsis[J].Crit Care Med,2000,28:N105~113.
[5] Le Tulzo Y, Pangault C, Gacouin A,et al. Early circulating lymphocyte apoptosis in human septic shock is associated with poor outcome[J].Shock,2002,18:487~494.
[6] Heffernan DS, Monaghan SF, Thakkar RK. Failure to normalize lymphopenia following trauma is associated with increased mortality, independent of the leukocytosis pattern[J].Crit Care,2012,16:R12.
[7] Menges T, Engel J, Welters I, et al. Changes in blood lymphocyte populations after multiple trauma: association with posttraumatic complications[J].Crit Care Med,1999,27:733~740.
[8] De Jager CP, van Wijk PT, Mathoera RB. Lymphocytopenia and neutrophil-lymphocyte count ratio predict bacteremia better than conventional infection markers in an emergency care unit[J].Crit Care,2010,14:R192.
[9] An X, Ding PR, Li YH, et al. Elevated neutrophil to lymphocyte ratio predicts survival in advanced pancreatic cancer[J].Biomarkers,2010,15:516~522.
[10] Azab B, Bhatt VR, Phookan J,et al. Usefulness of the neutrophil-to-lymphocyte ratio in predicting short- and long-term mortality in breast cancer patients[J].Ann Surg Oncol,2012,19:217~224.
[11] Sarraf KM, Belcher E, Raevsky E. Neutrophil/lymphocyte ratio and its association with survival after complete resection in non-small cell lung cancer[J].Thorac Cardiovasc Surg,2009,137:425~428.
[12] Muhmmed SM, Bahnacy JA, Ali AA. Predictive value of neutrophil to lymphocyte ratio in outcomes of patients with acute coronary syndrome[J].Arch Med Res,2010,41:618~622.
[13] Azab B, Jaglall N, Atallah JP, et al. Neutrophil-lymphocyte ratio as a predictor of adverse outcomes of acute pancreatitis[J].Pancreatology,2011,11:445~452.
[14] Akilli NB, Yortanli M, Mutlu H, et al. Prognostic importance of neutrophil-lymphocyte ratio in critically ill patients: short- and long-term outcomes[J].Am Emerg Med,2014,32:1476~1480.
[15] Salciccioli JD, Marshall DC, Pimentel MA, et al. The association between the neutrophil-to-lymphocyte ratio and mortality in critical illness: an observational cohort study[J].Crit Care,2015,19:13.