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Clinical Effect of Neurotropin Injection Combined with Spleen Aminopeptide in the Treatment of Herpes Zoster |
CHEN Lili, HE Lei, Qi Haihua, et al |
The Affiliated Hospital of Chengde Medical College, Hebei Chengde 067000, China |
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Abstract Objective: To explore the clinical effect of Neurotropin and spleen aminopeptide oral lyophilized powder in the treatment of herpes zoster. Methods: 60 patients with herpes zoster at early stage were randomly divided into two groups: treatment group and control group, 30 cases in each group. The control group were given acyclovir for a 0.25 g intravenous drip every 8 hours and cobamamide needle for 1.0 mg intramuscular injection everyday. On the basis of the treatment in the control group, treatment group were given Neurotropin 3.6IU on an intravenousdrip and spleen peptide oral lyophilized powder producing 2 mg by oral a day, the treatment course was 10 days.The pain degree of the patients was assessed by the methods of visual analogue scale (VAS), The sleep quality of the patients was determined by the methods of sleep quality score (QS), VAS and QS score changes the two groups before and after treatment were compared, the improved effect of neuralgia was observed. Results: VAS score of the two groups all significantly decreased before and after the treatment, QS score increased significantly, the difference was statistical significant (P < 0.05). VAS score of the treatment group was significantly lower than that of the control group, while QS score of the treatment group was significantly higher than that of the control group, the difference was statistically significant (P<0.001). Conclusion: The application of Neurotropin injection combined with spleen peptide on the treatment of herpes zoster at early stage can effectively improve the symptom of neuralgia patients , then consequently improve the life quality of patients.
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Fund:河北省承德市科学技术研究与发展计划项目,(编号:20151038) |
Corresponding Authors:
于淑萍
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[1] Fukuda Y,Berry TL,Nelson M,et al.Stimulated neuronal expression of brain-derived neurotrophic factor by Neurotropin[J].moL Cell Neurosci,2010,45:226~233. [2] 林大东,李萍妹.加巴喷丁和卡马西平治疗老年带状疱疹后神经痛临床观察[J].中华临床医师杂志,2012,6(15):4543~4544. [3] Fshner J,Bell AL.Herpes zoster and postherpetic neuralgia:prevention and management[J].Am Fam Physician,2011,83:1432~1437. [4] Okazaki R,Namba H,Yoshida H,et al.The antiallodynic effect of neurotropin is mediated via activation of descending pain inhibitory systems in rats with spinal nerve ligation[J].Anesth Analg,2008,107:1064~1069. [5] 陈岳.伐昔洛韦联合恩再适预防带状疱疹后神经痛的临床观察[J].医学综述,2013,19(3):552~553. |
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