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| Study on the Expression of Related Cytokines in the Serum of Patients with Diabetic Retinopathy |
| ZHANG Yanli, ZHAO Qi, et al |
| The People's Hospital of Zhongshan, Guangdong Zhongshan 528400, China |
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Abstract Objective: To investigate whether EGF,TGF2β,bFGF,TNF-α,CRP and PEDF affect diabetic retinopathy. Methods: Serum EGF,TGF2β,bFGF,TNF-α,CRP and PEDF were detected by ELISA in control, NDR, NPDR and PDR groups. Results: The serum levels of VEGF,TGF2β,bFGF,TNF-α,CRP in NDR,NPDR and PDR groups were higher than control group, while PEDF was lower (P<0.05). The serum levels of VEGF,TGF2β,bFGF,TNF-α,CRP in NPDR and PDR were higher than NDR group while PEDF was lower (P<0.05). The serum levels of VEGF,TGF2β,bFGF,TNF-α,CRPin PDR were higher than NPDR group, while PEDF was lower (P<0.05). Conclusion: Hyperglycaemia induced VEGF,TGF2β,bFGF,TNF-α,CRP levels and reduced PEDF, which aggravated the pathological changes in retina.
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| Fund:中山市科技计划项目,(编号:2016B1015);广东省省级科技计划项目,(编号:2014A020212052) |
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2017, Vol. 23 
