AbstractObjective: To analyze the influence of low-calcium dialysate on maintenance hemodialysis patients' secondary hyperparathyroidism and carotid atherosclerosis. Methods: 76 cases of maintenance hemodialysis patients were randomly divided into two groups, control group:high dialysate calcium concentration (DCa1.75), 3 times/week for 6 months; observation groups: low-calcium dialysate (DCa1.25), 3 times/week for 6 months. The peripheral blood PTH, calcium and phosphorus metabolism, lipid metabolism, ultrasound carotid artherosclerosis parameters before and after 6 months of two group patients were detected. Results: The PTH, calcium and phosphate metabolism, lipid metabolism, ultrasound carotid atherosclerosis parameters before treatment of two group patients showed no significant difference (P>0.05), The serum tCa, iCa, PTH contents of observation group patients were less than control group patients after 6 months treatment. P level was higher than control group patients (P<0.05); lipid metabolism parameters TC, TG,ApoB, LDL-C contents were less than control group patients, HDL-C level was higher than control group patients (P<0.05); serum content of SOD was higher than that in control group, contents of ROS and MDA were lower than those of control group (P<0.05); carotid ultrasound parameters IMT, CA-RI were lower than control group patients, Vmax, Vmin levels were higher than control group patients (P<0.05). Conclusion: For uremic patients, the concentration of calcium in the normal range, application of low calcium dialysate concentration helps to maintain the stability of calcium and phosphorus and the content of PTH, further progress in inhibition of carotid atherosclerosis, individualized dialysate calcium concentration is an important link to ensure the effect of dialysis in uremic patients, reduce serious complications.
[1] 袁志娟,程志强.非糖尿病维持性血液透析患者甲状腺水平情况及其与颈动脉硬化的相关性分析[J].中国医药导报,2016,13(4):56~59. [2] Ve eri -Haler ,Romozi K,Antoni M,et al.Comparison of the Pharmacological Effects of Paricalcitol Versus Calcitriol on SecondaryHyperparathyroidism in the Dialysis Population[J].Ther Apher Dial,2016,20(3):261~266. [3] 王蕴倩,陈宝平,时军,等.维持性血透患者亚临床甲状腺功能异常与颈动脉粥样硬化的相关性研究[J].中国现代药物应用,2016,10(10):31~34. [4] Chang CT,Wang GJ,Kuo CC,et al.Electronegative Low-density Lipoprotein Increases Coronary Artery Disease Risk in UremiaPatients on Maintenance Hemodialysis[J].Medicine (Baltimore),2016,95(2):e2265. [5] Kim SM,Kim M,Lee EK,Kim SB,Chang JW,Kim HW.The effect of zinc deficiency on salt taste acuity, preference, and dietary sodium intake inhemodialysis patients[J].Hemodial Int,2016,20(3):441~446. [6] Prka in I,Balenovic D,Cavri G,Bartolek D,Bulum T.Importance of standardized stepwise screening in patients with resistant hypertension[J].Acta Med Croatica,2014,68(2):111~115. [7] Lu JR,Yi Y,Xiong ZX,et al.The Study of Low Calcium Dialysate on Elderly Hemodialysis Patients with Secondary Hypoparathyroidism[J].Blood Purif,2016,42(1):3~8.
2017, Vol. 23 
