|
|
|
| The Value of Inflammation Based Index in Hepatocellular Carcinoma Prognosistic Patient |
| SUN Zhide, CHENG Limin, PING Ping, et al |
| The Affiliated Hospital of Chengde Medical College, Hebei Chengde 067000, China |
|
|
|
|
Abstract Objective: To investigate the usefulness of the inflammation based index (IBI) as prognostic factors in patients with hepatocellular carcinoma (HCC). Methods: A total of 119 HCC patients admitted in our hospital from July 2011 to July 2014 were enrolled in the study. The HCC patients were assigned according to the grade (0, 1, 2) of IBI. The correlations between IBI and clinic-pathologic features were detected in the study. The prognostic significance of IBC and barcelona clinic liver cancer (BCLC) were analyzed by univariate survival analysis. Results: The AFP level in human serum (P<0.05) and inntrahepatic metastasis (P<0.01) significantly increased in the HCC patients of the high IBI group compared with 0 grade IBI group. Child-Pugh class and BCLC had a significant difference between 0, 1, 2 IBI groups (P<0.01). The IBI grade negatively correlated with tumor-free survival time. Conclusion: The IBI score is consistent with the clinicopathological features and BCLC staging of HCC, which could be used as an effective indicator for the prognosis of HCC patients.
|
|
|
|
|
|
[1] 苗雄鹰,刘威,何招才,等.不同肝癌分期方法对肝癌肝切除患者预后价值的比较研究[J].中华肝胆外科杂志,2011,17(5):367~371.
[2] Pinato DJ, Stebbing J, Ishizuka M, et al. A novel and validated prognostic index in hepatocelluar carcinoma:the inflammation based index (IBI)[J].Hepatol,2012,57(5):1013~1020.
[3] 罗燕香,龚雪屹,季明芳,等.高尔基体蛋白73与AFP在原发性肝细胞癌筛查中的应用对比研究[J].中华临床医师杂志(电子版),2014,17:3089~3093.
[4] 杨学伟,蒋小峰,薛平,等.IBI评分对肝癌术后预后的预测价值[J].广东医学,2013,34(11):1688~1690.
[5] Cuka K, et al. Clinical features and prognosis of patients with extrahepatic metastases from hepatocellular carcinoma[J].World Gastroenterol,2007,13: 414~420.
[6] Uchino K, et al. Hepatocellular carcinoma with extrahepatic metastasis: Clinical features and prognostic factors[J].Cancer,2011,117:4475~4483.
[7] Zidan A,Scheuerlein H,Schule S,et al.Epidemiological pattern of hepatitis B and hepatitis C as etiological agents for hepatocellular carcinoma in iran and worldwide[J].Hepat Mon, 2012, 12(10HCC):e6894.
[8] Li Z, et al. Genetic polymorphisms of immune checkpoint proteins PD-1 and TIM-3 are associated with survival of patients with hepatitis B virus-related hepatocellular carcinoma[J].Oncotarget,2016,7(18):26168~26180. |
| [1] |
. [J]. 河北医学, 2017, 23(8): 1401-1403. |
|
|
|
|
2017, Vol. 23 
