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| The Relationship between Ghrelin Gene Polymorphism and Essential Hypertension in Patients with Risk Factors |
| LIU Bin, et al |
| The People's Hospital of Cangzhou, Hebei Cangzhou 061000, China |
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Abstract Objective: To investigate the relationship between the human growth hormone releasing peptide (Ghrelin) and the essential hypertension. methods: 80 cases of patients with essential hypertension were studied and 80 cases of healthy were selected from October 2014 to October. The Ghrelin gene polymorphism assays of two groups were used with TaqMan-PCR method and Ghrelin gene polymorphism in patients with risk factors for hypertension were analyzed. Results: Compared with the control group, patients with hypertension CC, CA, AA genotype frequency distribution was 68.75%, 17.50%, 13.75%, allele C, A frequencies were 0.185,0.875, the control group were 18.75% , 35.00%, 46.25%, allele C, a frequencies were 0.125,0.815. Ghrelin gene CC type serum triglycerides in patients with hypertension (TC), low density lipoprotein (LDL-C), total cholesterol (TG), systolic blood pressure (SBP), diastolic blood pressure (DBP), waist-hip ratio (WHR), body mass (BMI) were significantly higher than those of CA and AA genotype (P <0.05), whereas HDL-C and lower than the CA type AA type (P<0.05). Chi square and Logistic multivariate analysis showed that the Ghrelin gene type CC was associated with TC abnormalities, LDL-C abnormalities, SBP abnormalities, DBP abnormalities, and BMI abnormalities. Conclusion: Ghrelin gene polymorphism and risk factors lead to high blood pressure, such as abnormal TC, LDL-C exception, SBP abnormality, DBP abnormality, BMI and abnormal, and therefore, Ghrelin gene polymorphism may be involved in essential hypertension pathogenesis.
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2017, Vol. 23 
