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河北医学  2018, Vol. 24 Issue (7): 1121-1124    DOI: 10.3969/j.issn.1006-6233.2018.07.016
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结直肠癌患者血清脂联素瘦素及其受体表达与临床病理参数的关系
江勇, 谭卫林, 韩潞, 刘兵, 韩东兴
上海市建工医院普外科, 上海 200083
Relationship between Serum Adiponectin, Leptin and The Receptors Expression and Clinicopathological Parameters in Patients with Colorectal Cancer
JIANG Yong, TAN Weilin, HAN Lu, et al
Shanghai Jiangong Hospital, Shanghai 200083, China
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摘要 目的: 探讨脂联素(Adiponectin,ADPN)、脂联素受体(adiponectin receptor 2,adipoR2)、瘦素(Leptin,LP)和瘦素受体(Leptin Receptor,LEPR)在结直肠癌患者发病风险、发展及转移的关系。 方法: 选取2012年1月至2014年12月在我院肛肠科住院,经术后病理证实( 根据肿瘤类型、细胞形态及浸润深度等)的结直肠癌患者43例作为病例组,同时选取同期于我院经肠镜检查无正常的健康体检的健康志愿者31例作为对照组,收集一般临床资料,用ELISA测定血清中ADPN和LP水平,用实时荧光RT-PCR检测adipoR2和LEPR mRNA的表达。 结果: 与对照组比较,病例组BMI、FBG、TC、HDL-C、LDL-C、TG差异无统计学意义(t=0.78、0.23、0.64、0.93、0.19、0.99,P>0.05),有结直肠癌患者家族史患结直肠癌的患病率增高,差异具有统计学意义(χ2=12.13,P<0.05);与对照组比较,血清中ADPN的含量和adipoR2 mRNA表达量降低,血清中LP含量和LEPR mRNA表达量增加,差异有统计学意义(t= 2.53、4.29、4.75、6.24,P<0.05);与Ⅰ期组比较,血清中ADPN的含量和adipoR2 mRNA表达量随着结直肠癌TNM分期增加而降低,血清中LP的含量和LEPR mRNA表达量随着结直肠癌TNM分期增加而增加,差异有统计学意义(F= 9.90、3.52、8.70、9.21,P<0.05);血清中ADPN的含量和adipoR2 mRNA表达量与TNM分期的生存期呈负相关(r=-0.335、-0.341、-0.557、-0.492、-0.665、-0.757、-0.815、-0.753,P<0.05),与LP的含量和LEPR mRNA表达量与TNM分期的生存期呈正相关(r=0.396、0.516、0.510、0.641、0.642、0.628、0.695、0.682,P<0.05)。 结论: ADPN水平和LP水平及其受体表达量可作为诊断结直肠癌的一个标志物。ADPN水平和其受体表达量在结直肠癌患者血清中中显著降低,LP水平和其受体表达量在结直肠癌患者血清中显著增高。
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关键词 结直肠癌脂联素脂联素受体瘦 素瘦素受体    
AbstractObjective: To investigate the risk, development and metastasis of Adiponectin (ADPN), adiponectin receptor 2 (adipoR2), Leptin (LP) and leptin receptor (LEPR) in patients with colorectal cancer. Methods: 43 patients with colorectal cancer hospitalized in the proctology department of our hospital and confirmed by pathology (tumor type, cell morphology and invasion depth) were enrolled into case group, 31 healthy individuals were included into control group, the general clinical data of all the selected subjects were collected. The levels of ADPN and LP in serum were measured by ELISA, and the expression of adipoR2 and LEPR mRNA was detected by RT-PCR. Results: The BMI, FBG, TC, HDL-C, LDL-C and TG between the two groups had no significant difference (t=0.78, 0.23, 0.64, 0.93, 0.19, 0.99, P>0.05), the prevalence rate of colorectal cancer in patients with family history of colorectal cancer was higher than those patients without the family disease history, the differences were statistically significant (χ2=12.13, P<0.05); The ADPN levels and adipoR2 mRNA expression level in serum were lower than those in the control group, and the LP levels and LEPR mRNA expression level in serum were higher than those in the control group (t=2.53, 4.29, 4.75, 6.24, P<0.05); Compared with patients in stageⅠ, The ADPN levels and adipoR2 mRNA expression level in serum decreased with the increase of TNM staging in colorectal cancer, and the LP levels and LEPR mRNA expression level in serum increased with the increase of TNM staging in colorectal cancer (F=9.90, 3.52, 8.70, 9.21, P<0.05); The ADPN levels and adipoR2 mRNA expression level in serum were negatively correlated with TNM stage (r=-0.335, -0.341, -0.557, -0.492, -0.665, -0.757, -0.815, -0.753, P<0.05), while the LP levels and LEPR mRNA expression level were positively correlated with TNM stage (r=0.396, 0.516, 0.510, 0.641, 0.642, 0.628, 0.695, 0.682, P<0.05). Conclusion: ADPN levels and LP levels and their receptor expression can be used as a marker for the diagnosis of colorectal cancer. In colorectal cancer patients, the level of ADPN and its receptor expression are significantly decreased, and the level of LP and its receptor expression are increased significantly.
Key wordsColorectal cancer    ADPN    AdipoR2    LP    LEPR
    
基金资助:上海市虹口区卫生计划生育委员会医学科研课题,(编号:虹卫1503-25)
引用本文:   
江勇, 谭卫林, 韩潞, 刘兵, 韩东兴. 结直肠癌患者血清脂联素瘦素及其受体表达与临床病理参数的关系[J]. 河北医学, 2018, 24(7): 1121-1124.
JIANG Yong, TAN Weilin, HAN Lu, et al. Relationship between Serum Adiponectin, Leptin and The Receptors Expression and Clinicopathological Parameters in Patients with Colorectal Cancer. HeBei Med, 2018, 24(7): 1121-1124.
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