果酸联合胶原蛋白敷料CO<sub>2</sub>点阵激光治疗面部痤疮凹陷性瘢痕的临床观察

doi:10.3969/j.issn.1006-6233.2019.07.035

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摘要目的: 研究果酸联合胶原蛋白敷料、CO₂点阵激光(CO₂FL)治疗面部痤疮凹陷性瘢痕的临床疗效。方法: 将我院2016年4月至2017年4月收治的98例面部痤疮凹陷性瘢痕患者随机分为研究组(49例)和对照组(49例),两组均给予CO₂FL、胶原蛋白敷料治疗,研究组加用果酸治疗,比较两组治疗4个疗程后的疗效、温哥华瘢痕量表(VSS)评分、误工期、患者满意度等情况。结果: 组间与时间点交互效应差异有统计学意义(P<0.05),两组患者治疗后ECCA评分均低于治疗前(P<0.05);研究组治疗后总有效率为97.96%,显著高于对照组的83.67%(P<0.05);研究组VSS评分治疗前后差值明显大于对照组(P<0.05);研究组治疗后总满意率为93.88%,显著高于对照组的75.51%(P<0.05);研究组平均误工期明显短于对照组(P<0.05),研究组不良反应发生率为24.48%,显著低于对照组的8.16%(P<0.05)。结论: 果酸联合胶原蛋白敷料、CO₂FL治疗面部痤疮凹陷性瘢痕疗效确切,可有效改善患者瘢痕状况,缩短误工期,且安全性较高,值得推广借鉴。

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关键词 ：果酸, CO₂点阵激光, 胶原蛋白敷料, 痤疮, 凹陷性瘢痕

Abstract：Objective: To study the clinical curative effect of tartaric acid combined with collagen dressing and CO₂ fractional laser (CO₂FL)in the treatment of facial spitted acne scars. Methods: 98 patients with facial spitted acne scars treated in our hospital during the period from April 2016 to April 2017 were randomly divided into the study group (49 cases) and the control group (49 cases). The two groups were treated with CO₂ fractional laser and collagen dressing, and the study group were additionally treated with tartaric acid. The curative effect, Vancouver scar scale (VSS) score, time of work delays and patient's satisfaction were compared between the two groups after 4 courses of treatment. Results: There were statistically significant differences in the interaction effects of between-groups and time points (P<0.05), and ECCA scores of two groups after treatment were lower than those before treatment (P<0.05). The total effective rate after treatment of the study group was significantly higher than that of the control group (97.96% vs 83.67%) (P<0.05). The difference of VSS score before and after treatment of the study group was significantly greater than that of the control group (P<0.05). After treatment, the total satisfaction rate of the study group was significantly higher than that of the control group (93.88% vs 75.51%) (P<0.05). The mean time of work delays of the study group was significantly shorter than that of the control group (P<0.05).The incidence rate of adverse reactions in the study group was significantly lower than that in the control group (24.48% vs8.16%) (P<0.05). Conclusion: Tartaric acid combined with collagen dressing and CO₂FL is effective in the treatment of facial spitted acne scars. The regimen can effectively improve the scar status of patients and shorten the time of incapacity, with high safety.

Key words： Tartaric acid CO₂ fractional laser Collagen dressing Acne Spitted scar

基金资助:陕西省科学技术研究发展计划项目,(编号:S2015YFSF510748)

通讯作者: 李锋

引用本文:

靳艳茹, 杨帆, 刘孝兵, 李雅琴, 宋印娥, 李锋. 果酸联合胶原蛋白敷料CO₂点阵激光治疗面部痤疮凹陷性瘢痕的临床观察[J]. 河北医学, 2019, 25(7): 1186-1189.
JIN Yanru, YANG Fan, LIU Xiaobing, et al. Clinical Observation of Fructonic Acid Combined with Collagen Dressing and CO₂ Lattice Laser in the Treatment of Facial Acne Depressed Scar. HeBei Med, 2019, 25(7): 1186-1189.

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http://www.hbyxzzs.cn/CN/10.3969/j.issn.1006-6233.2019.07.035 或 http://www.hbyxzzs.cn/CN/Y2019/V25/I7/1186