Abstract：Objective: To explore the changes of CD68 and bFGF levels in tissues of patients with benign prostatic hyperplasia and their effects in clinical practice. Methods: 68 cases of patients with benign prostatic hyperplasia confirmed by pathological biopsy who were treated in our hospital from June 2016 to December 2017 were selected as observation group, and another 52 cases of patients with prostatic inflammation were included in control group. The prostate volume and IPSS, urinary symptoms and pain and discomfort scores were analyzed in the two groups. The changes of CD68 and bFGF levels in prostate tissues were determined by immunohistochemistry in the two groups. Results: Compared with control group, the prostate volume of benign prostate patients was increased significantly (P<0.05). IPSS, urinary symptoms and pain discomfort scores were increased significantly (P<0.05). There was no statistically significant difference in the pain and discomfort scores between the two groups (P>0.05). In the immunohistochemistry experiment, compared with control group, the levels of CD68 and bFGF in the tissues of patients with benign prostate were significantly increased (P<0.05). The benign prostate status was positively correlated with the concentrations of CD68 and bFGF in the tissues (r=0.426, 0.401, P<0.05). Conclusions: The changes of CD68 and bFGF levels in tissues of patients with benign prostate are positively correlated with pathological status, and they may provide a reference for the diagnosis and treatment of patients with benign prostatic hyperplasia in clinical practice.
韩卫军, 李涛. CD68和bFGF在良性前列腺增生组织中的表达及临床意义[J]. 河北医学, 2019, 25(7): 1132-1134.
HAN WeiJun, et al. Expression and Clinical Significance of CD68 and bFGF in Benign Prostatic Hyperplasia Tissues. HeBei Med, 2019, 25(7): 1132-1134.
[1] 曹乃龙,陆奇杰,王啸虎,等.良性前列腺增生患者前列腺超声测定参数与年龄的相关性分析[J].中华男科学杂志,2017,23(4):315~318. [2] Kang B J,Wang Y,Zhang L,et al.bFGF and VEGF improve the quality of vitrified-thawed human ovarian tissues after xenotransplantation to SCID mice.[J].Journal of Assisted Reproduction&Genetics,2016,33(2):281~289. [3] Izumi K,Mizokami A,Lin W J,et al.Androgen receptor roles in the development of benign prostate hyperplasia[J].American Journal of Pathology,2013,182(6):1942~1949. [4] 郝晟瑜,邱春红,柳腾,等.CD169+巨噬细胞在自身免疫性疾病中的研究进展[J].中国免疫学杂志,2017,33(6):934~938.
2019, Vol. 25 
冀公网安备13080202000677号