司来吉兰联合普拉克索对帕金森病合并睡眠障碍患者精神行为症状认知障碍及日常生活能力的影响

doi:10.3969/j.issn.1006-6233.2019.07.005

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摘要目的: 探讨司来吉兰联合普拉克索治疗对帕金森病(PD)合并睡眠障碍患者精神行为症状、认知障碍及日常生活能力的影响。方法: 将我院80例PD合并睡眠障碍患者按照简单随机分组法分为对照组40例和观察组40例,对照组给予普拉克索治疗,观察组给予司来吉兰联合普拉克索治疗,比较两组患者神经精神调查问卷(NPI)评分、简易精神状态检查表(MMSE)评分、匹兹堡睡眠指数评估量表(PSQI)评分、Epworth嗜睡量表(ESS)评分、统一PD评定量表运动检查(UPDRS-Ⅲ)评分和日常生活活动能力量表(ADL)评分,以及不良反应。结果: 治疗后,观察组NPI、PSQI、ESS、UPDRS-Ⅲ评分低于对照组(P<0.05),MMSE、ADL评分高于对照组(P<0.05),两组不良反应发生率无显著差异(P>0.05)。结论: 司来吉兰联合普拉克索治疗可显著改善PD合并睡眠障碍患者精神行为症状,减轻认知障碍,增强日常生活能力,且无明显不良反应。

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关键词 ：帕金森病, 司来吉兰, 普拉克索, 睡眠障碍, 精神行为症状, 认知障碍

Abstract：Objective: To investigate the effects of selegiline combined with pramipexole on behavioral and psychological symptoms, cognitive disorders and activity of daily living of patients with Parkinson's disease (PD) complicated with sleep disorders. Methods: 80 patients with PD and sleep disorders in the hospital were divided into control group (n=40) and observation group (n=40) by the simple random grouping method. The control group was treated with pramipexole while the observation group was treated with selegiline combined with pramipexole. Scores of neuropsychiatric inventory (NPI), mini-mental state examination (MMSE), Pittsburgh sleep quality index (PSQI), Epworth sleepiness scale (ESS), Unified Parkinson’s Disease Rating Scale (UPDRS-III) and activities of daily living (ADL), as well as adverse reactions were compared between the two groups. Results: Scores of NPI, PSQI, ESS and UPDRS-III of the observation group were lower than those of the control group after treatment (P<0.05), while scores of MMSE and ADL were higher than those of the control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: Selegiline combined with pramipexole can significantly improve the behavioral and psychological symptoms of patients with PD and sleep disorders, reduce cognitive disorders, and enhance activity of daily living, without obvious adverse reactions.

Key words： Parkinson's disease Selegiline Pramipexole Sleep disorders Behavioral and psychological symptoms Cognitive disorders

基金资助:辽宁省科技攻关计划项目,(编号:20152056742)

引用本文:

王阳, 徐冰, 周进, 李莉, 林媛媛. 司来吉兰联合普拉克索对帕金森病合并睡眠障碍患者精神行为症状认知障碍及日常生活能力的影响[J]. 河北医学, 2019, 25(7): 1078-1080.
WANG Yang, XU Bing, ZHOU Jin, et al. Effects of Selegiline Combined with Pramipexole on Behavioral and Psychological Symptoms Cognitive Disorders and ADL of Patients with Parkinson's Disease Complicated with Sleep Disorders. HeBei Med, 2019, 25(7): 1078-1080.

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http://www.hbyxzzs.cn/CN/10.3969/j.issn.1006-6233.2019.07.005 或 http://www.hbyxzzs.cn/CN/Y2019/V25/I7/1078