Abstract：Objective: To investigate the value of dynamic monitoring of neutrophil/lymphocyte ratio (NLR) in the assessment of early neonatal hypoxic ischemic encephalopathy (HIE). Methods: 86 children with HIE in our hospital (November 2016-October 2018) were enrolled in the study group, and 86 normal newborns were selected as the control group. All the newborns were given 2 ml of blood samples on the 1st, 3rd and 7th day after delivery, and the neutrophil and lymphocyte values were detected by automatic blood cell analyzer, and NLR was calculated. Statistically analyze the neutrophil value, lymphocyte value, NLR, and statistical analysis of neutrophil values and lymphocytes on the 1st, 3rd and 7th day after delivery in the study group and the control group and the study group. Cell values, NLR and HIE severity were correlated. Results: The neutrophil value and NLR of the study group were higher than those of the control group on the 1st and 3rd day after delivery (P<0.05). There was no significant difference between the lymphocyte values and the control group and the 7th day after delivery (P>0.05). There were no significant differences in neutrophil value and lymphocyte value, NLR between the study group and control group (P>0.05). The neutrophil value and NLR were higher in children with severe HIE on the 1st and 3rd day after delivery. (P<0.05). There was no significant difference among lymphocyte values in children with mild HIE (P>0.05), neutrophil value and lymphocyte value, NLR in children with severe HIE on the 7th day after delivery. There was no significant difference among children with mild HIE (P>0.05). Spearman's test showed that there was a significant positive correlation between neutrophil value (r=0.801) and NLR (r=0.796) and HIE severity (P<0.05), there was no significant correlation between lymphocyte values (r=0.467) and HIE severity (P>0.05). Conclusion: The neutrophil value and NLR abnormality increase in the first 3 days after delivery of HIE children, and the increase rate increases with the severity of the disease. There is a significant positive correlation between the two, and the clinical manifestation of HIE can be assessed by dynamic monitoring of NLR, providing a reference for clinical development and adjustment of treatment plans.
温晓芳. NLR动态监测在早期新生儿缺氧缺血性脑病病情评估中的应用价值[J]. 河北医学, 2019, 25(6): 927-930.
WEN Xiaofang. Application Value of NLR Dynamic Monitoring in the Assessment of Early Neonatal Hypoxic Ischemic Encephalopathy. HeBei Med, 2019, 25(6): 927-930.
2019, Vol. 25 
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