Effect of Low-dose Clarithromycin combined with Endoscopic Nasal Septum Correction and Sinus Opening for Chronic Rhinosinusitis Patients with ECP and TIgE Levels
LI Dongbo, HAN Jinhua, GAO Wei
Xinhua Hospital Affiliated to Dalian College, Liaoning Dalian 116021, China
Abstract：Objective: To investigate the therapeutic effect of low-dose clarithromycin combined with endoscopic nasal septum correction and sinus open surgery on chronic rhinosinusitis (CRS) patients and serum eosinophil cationic protein (ECP) and total immunoglobulin E(TIgE) levels. Methods: From February 2016 to April 2018, 124 patients with CRS in our hospital were selected and divided into control group (n=62) and experimental group (n=62) according to simple randomization. The control group underwent endoscopic nasal septum correction and sinus open surgery. The test group was treated with low-dose clarithromycin combined with endoscopic nasal septum correction and sinus open surgery. The therapeutic effects of the two groups after surgery were compared with those of preoperative, postoperative, 1 month, and 3 months postoperative serum ECP, TIgE levels, and inflammatory factors [interleukin-6 (IL-6), tumor necrosis factor- α(TNF-α)] level, quality of life score (SF-36). Results: The total effective rate of the test group was 93.55% at 3 months after operation, which was higher than that of the control group (P < 0.05). The serum ECP, TIgE, IL-6, The TNF-α level showed a decreasing trend, and the serum levels of the above test group decreased greatly. The two groups of serum ECP, TIgE, IL-6, TNF-α levels, different time points and interactions between groups and at different time points The difference was statistically significant (P<0.05). The SF-36 scores increased at 1 month and 3 months after operation, and the SF-36 score increased significantly in the experimental group. SF-36 There were significant differences in the interaction between the score groups, at different time points, and between groups at different time points (P<0.05). Conclusion: Low-dose clarithromycin combined with endoscopic nasal septum correction and sinus open surgery in patients with chronic rhinosinusitis can improve the therapeutic effect, reduce serum ECP and TIgE levels, reduce the body's inflammatory response and improve the quality of life of patients.
李东波, 韩锦华, 高伟. 低剂量克拉霉素联合鼻内镜下鼻中隔矫正术及鼻窦开放术对慢性鼻-鼻窦炎患者治疗效果及ECP TIgE水平的影响[J]. 河北医学, 2019, 25(6): 881-885.
LI Dongbo, HAN Jinhua, GAO Wei. Effect of Low-dose Clarithromycin combined with Endoscopic Nasal Septum Correction and Sinus Opening for Chronic Rhinosinusitis Patients with ECP and TIgE Levels. HeBei Med, 2019, 25(6): 881-885.
2019, Vol. 25 
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