Abstract：Objective: To investigate the changes of CD3 + CD4+ and CD3+CD8+ lymphocyte percentage in children with hand, foot and mouth disease (HFMD). Methods: 90 children with severe hand, foot and mouth disease admitted to our hospital from June 2016 to June 2018 were selected as the patient group, and 90 healthy children who came to our hospital for physical examination during the same period were selected as the control group. The levels of peripheral blood lymphocyte subsets, zinc in erythrocyte and high-sensitivity C-reactive protein were measured in two groups. The changes of CD3+, CD3+CD4+, CD3+CD8+lymphocyte percentage and hs-CRP level were analyzed. Results: The percentages of CD3+CD8+, CD3+CD4+, CD3+CD3+in the patients group were significantly lower than those in the control group (t=5.349, t=4.384, t=5.304, all P<0.05). The percentages of CD3+CD8+, CD3+CD4+, CD3+CD3+in the patients group were significantly lower than those in the control group (t=5.349, t=4.384, t=5.304, all P<0.05). The level of high-sensitivity C-reactive protein in the patients group was (5.54 +1.98) mg/L, which was significantly higher than that in the control group (1.67 +1.21) mg/L (t=4.958, P<0.05). The zinc level of erythrocyte in the children of the same age group was significantly lower than that in control group (all P<0.05). Conclusion: The humoral and cellular immune function of children with severe hand, foot and mouth disease is in disorder to a certain extent. The body lacks zinc of red blood cells, and can not form effective resistance to virus infection, and can further form secondary bacterial infection.
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2019, Vol. 25 
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