Abstract：Objective: To explore the influence on development of tissue T lymphocytes (CD3+), macrophages (CD68+), matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) in patients with abdominal aortic aneurysm (AAA). Methods: The abdominal aortic aneurysm tissue obtained from 101 patients with AAA admitted to our hospital from May 2017 to June 2018 was selected as the observation group, at the same time, 20 normal abdominal aorta tissues were selected as the control group.The expression of CD3+, CD68+, MMP-2 and MMP-9 in the above tissues was detected by immunohistochemistry, and quantitative analysis was performed by image analysis technique. Results: The expressions of CD3+ (100.43±105.81) and CD68+ (233.01±195.31) in the AAA tissues of the observation group were significantly higher than those in the control group, and the difference was statistically significant (P<0.05);the expression of MMP-2 (0.098±0.047) and MMP-9 (0.025±0.015) in the AAA tissues of the observation group was higher than that of the control group, and the difference was statistically significant (P<0.05). Conclusion: The large expression of CD3+, CD68+, MMP-2 and MMP-9 in AAA tissue can further promote the formation and expansion of AAA
张燕萍, 王敏, 甘树杰. 组织CD3+ CD68+ MMP-2与MMP-9对患者 腹主动脉瘤病情发生发展的影响[J]. 河北医学, 2019, 25(4): 551-553.
ZHANG Yanping, WANG Min, GAN Shujie. Effects of Tissue CD3+ CD68+ MMP-2 and MMP-9 on the Development of Abdominal Aortic Aneurysm in Patients. HeBei Med, 2019, 25(4): 551-553.
[1] Certik B, Treska V, Molacek J, et al.Our experience with left-sided retroperitoneal approach to resection of abdominal aortic aneurysm[J]. Rozhledy v chirurgii : mesicnik Ceskoslovenske chirurgicke spolecnosti,2018,97(2):88~93. [2] Agrawal A , Snow R , Lehman E ,et al.Factors affecting patients' functional status and their impact on outcomes of ruptured abdominal aortic aneurysms[J].Journal of vascular surgery,2018,68(3):712~719. [3] 王威,李方达,聂皓,等.T淋巴细胞在腹主动脉瘤发病机制中的作用[J].中华老年多器官疾病杂志,2017,16(10):762~765. [4] 刘端,李方达,廖鹏志,等.他汀类药物对腹主动脉瘤患者血清炎性因子的调节作用[J].中国医学科学院学报,2018,40(1):78~82. [5] 左尚维,隗瑛琦,陈峰等.腹主动脉瘤危险因素的病例对照研究[J].北京大学学报(医学版),2014,(3):412~416. [6] Climent E, Benaiges D, Chillaron JJ,et al.Diabetes mellitus as a protective factor of abdominal aortic aneurysm: possible mechanisms[J].Clinica e investigacion en arteriosclerosis : publicacion oficial de la Sociedad Espanola de Arteriosclerosis,2018,30(4):181~187. [7] 黄宝骏,赵刚,杨澄宇,等.腹主动脉瘤壁组织CD3+、CD68+及基质金属蛋白酶-2、基质金属蛋白酶-9的炎症发病机制[J].中华实验外科杂志,2018,35(3):513~515.
2019, Vol. 25 
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