Relationship between HPV16/18 Infection and Expression of PDGFR- and PDGFR- beta Protein in Cancer Tissues of Elderly Patients with Cervical Squamous Cell Carcinoma
ZHANG Yufang, REN Chunli, HOU Jing, et al
The Affiliated Hospital of Chengde Medical College, Hebei Chengde 067000, China
Abstract：Objective: The relationship between the expression of HPV16/18 infection and the expression of platelet derived growth factor receptor alpha (platelet-derived growth factor receptor-alpha, PDGFR- a) and platelet derived growth factor receptor beta (platelet-derived growth factor receptor-alpha, PDGFR- beta) in the elderly patients with squamous cell carcinoma of the cervix and the expression of platelet derived growth factor receptor beta (platelet-derived growth factor receptor-alpha, PDGFR- beta) and the relationship between the three The relationship between each other.Methods:75 cases of senile cervical squamous cell carcinoma and 32 of normal cervical tissue were selected. In situ hybridization was used to detect HPV16 /18 infection, and PDGFR- A and PDGFR- beta protein were detected by immunohistochemistry. Results:The infection rates of HPV16 /18 in cervical squamous cell carcinoma group and control group were 69.33% (52 /75) and 18.75% (6 /32) respectively.The infection rate of HPV16 /18 in elderly patients with cervical squamous cell carcinoma was significantly higher than that in the control group (P <0. 05). One case of PDGFR-α protein expression was detected in the control group, Positive expression rate 3.13%. In the elderly patients with cervical squamous cell carcinoma, 59 cases of PDGFR-α protein were detected positively, Positive expression rat 78.67%, and the difference was statistically significant. (P<0.05); The positive expression rate of PDGFR-α protein was related to the clinical stage of cervical squamous cell carcinoma patients (P<0.05); The positive expression rate of PDGFR-β protein was lower in the control group was 6.25%, and the cervical squamous cell carcinoma patients The expression rate of PDGFR-β protein in tissues was 62.67%, and the difference was statistically significant (P<0.05). The expression of PDGFR-β protein was correlated with the clinical stage of cervical scales (P<0.05); Among 72 cases of cervical squamous cell carcinoma, 47 cases (Positive expression rat 62.67%) were HPV16/18 positive, 45 cases (Positive expression rat 95.74%) were PDGFR-α protein positive, 40 cases (Positive expression rat 85.11%) were PDGFR-β protein positive.The number of HPV16/18 positive cervical squamous cell carcinoma patients was significantly higher than that of non-HPV16/18 positive cervical squamous cell carcinoma patients (P < 0.05).Spearman correlation analysis showed that the expression of PDGFR-α and PDGFR-β protein was positively correlated with HPV16/18 infection in patients with cervical cancer (rs=0.428,P<0.05; rs=0.562,P<0.05).PDGFR-α was positively correlated with the expression of PDGFR-β protein in cervical cancer patients (rs=0.639, P<0.05).Conclusions:Senile cervical squamous cell carcinoma is closely related to HPV16/18 infection. The expression of PDGFR-α and PDGFR-β protein in HPV16/18 infected cervical squamous cell carcinoma is significantly increased.It plays a synergistic role in the occurrence and development of cervical squamous cell carcinoma
张玉芳, 任春丽, 侯敬, 张金环, 郭艳巍, 唐明霞. 老年宫颈鳞癌患者HPV16/18感染与癌组织PDGFR-α 和PDGFR-β蛋白表达的关系[J]. 河北医学, 2019, 25(4): 543-547.
ZHANG Yufang, REN Chunli, HOU Jing, et al. Relationship between HPV16/18 Infection and Expression of PDGFR- and PDGFR- beta Protein in Cancer Tissues of Elderly Patients with Cervical Squamous Cell Carcinoma. HeBei Med, 2019, 25(4): 543-547.
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2019, Vol. 25 
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