Abstract：Objective: To determine the effective dose of dexmedetomidine (ED50) and 95% effective dose of dexmedetomidine (ED95) for sedation before operation in children. Methods: The American Society of Anesthesiologists (ASA) Grade I, aged from September to 5 years, was selected to perform laparoscopic high ligation of indirect inguinal hernia sac under general anesthesia in 30 children. One hour before operation, small volume fractional administration of dexmedetomidine: dexmedetomidine was not diluted, 0.1 ml or 10 UG was taken with a small spoon every time, every 3 minutes, less than 0.1 ml was taken at one time until the end of the treatment. According to the sedative effect of the previous case, the next case increased or decreased by 0.25 ug/kg. The ED50, ED95 and 95% CI of dexmedetomidine were calculated by probabilistic unit regression analysis. Results: The ED50 of small volume fractional administration of dexmedetomidine was 2.295 ug/kg, (95% CI: 2.170-2.422 ug/kg) and ED95 was 2.564, (95% CI: 2.472-3.294 ug/kg). Conclusion: Small volume fractional administration of dexmedetomidine for pediatric preoperative sedation has better compliance and higher oral mucosal absorption rate. The ED50 determined by modified sequential method is 2.295 ug/kg and ED95 is 2.564 ug/kg.
周少武, 杨坤, 刘宏强, 刘克超. 小容量分次含服右美托咪定在小儿术前镇静的有效剂量[J]. 河北医学, 2019, 25(3): 683-684.
ZHOU Shaowu, YANG Kun, LIU Hongqiang, et al. Effective Dose of Small Volume Fractional Dexmedetomidine for Preoperative Sedation in Children. HeBei Med, 2019, 25(3): 683-684.
2019, Vol. 25 
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