Abstract：Objective: To investigate the effect of intravenous and local combination of tranexamic acid on fibrinolytic activity and blood loss in patients undergoing total knee arthroplasty. Methods: 100 cases of knee replacement patients treated in our hospital from March 2015 to March 2018 were randomly divided into observation group (n=52) and control group (n=48). The control group was treated with local medication, while the observation group was treated with intravenous and local combined medication. Hemoglobin, hematocrit, fibrinogen (FIB), D-dimer (D-D), maximum loss of hemoglobin, total drainage, occult blood loss, total blood loss, blood transfusion patients and subcutaneous ecchymosis area were compared between the two groups before and after operation. Results: There was no significant difference in hemoglobin and blood cell contents before operation between the two groups. After surgery, the hemoglobin and blood cell contents of the two groups were significantly decreased, and the hemoglobin and blood cell contents of the observation group were significantly higher than those of the control group (P<0.05). There was no significant difference in the level of fibrinolysis before operation between the two groups. After surgery, FIB and d-d were significantly increased in both groups, and FIB and d-d were significantly lower in the observation group than in the control group (P<0.05). After surgery, the maximum hemoglobin loss, total outflow, recessive blood loss, total blood loss, blood transfusion patients and subcutaneous blood stasis area of the observation group were significantly lower than those of the control group (P<0.05). Conclusion: The use of tamaric acid vein combined with local medication in total knee replacement patients has significant effect, which can effectively reduce the blood loss and blood transfusion rate of patients, and is worthy of promotion and application.
孙博, 王静悦, 李冀. 氨甲环酸静脉与局部联合用药对全膝关节置换患者围术期纤溶活性与失血量的影响[J]. 河北医学, 2019, 25(3): 667-670.
SUN Bo, et al. Effect of Intravenous and Local combination of Tranexamic Acid on Fibrinolytic Activity and Blood Loss in Patients Undergoing Total Knee Arthroplasty. HeBei Med, 2019, 25(3): 667-670.
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2019, Vol. 25 
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